铜肠道稳态平衡调控机制研究进展

doi:10.16431/j.cnki.1671-7236.2017.09.018

Abstract

Abstract:

Copper is one of the necessary trace elements in animals. The absorption, storage, release and transportation of cellular copper in intestinal play an critical role in maintaining intracellular copper homeostasis, the imbalance of which can lead to intestinal dysfunction resulting from intestinal cell shedding.As for the gradually further and perfect studying on intestinal copper transporter and target organelles, people have achieved new discoveries and understanding. This article reviewed the binding pathway between intracellular mitochondria, golgi apparatus, cytoplasm and copper chaperone, as well as copper transporters. The expression mechanism of CTR1 transporters, redistribution mechanism of ATP7A and ATP7B in the case of high copper and homeostatic mechanism of other epithelial tissue copper were elucidated.Based on the above mechanism, the change of homeostasis in the intestine is a dynamic equilibrium which is related to the intestinal copper level and the expression of copper transporter in intestinal subcellular organelle,such as expression location and expression level. The conclusion will provide a theoretical foundation for revealing the mechanism of intestinal copper homeostasis.

Key words: enterocyte; copper homeostasis; copper transporter; copper chaperone protein

CLC Number:

S816.72

LIU Bo, YANG Wen-yan, YANG Lian-yu. Research Progress on Regulation Mechanisms of Intestinal Copper Homeostasis[J]. , 2017, 44(9): 2662-2667.

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Research Progress on Regulation Mechanisms of Intestinal Copper Homeostasis

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