狂犬病病毒糖蛋白生物学功能研究进展

doi:10.16431/j.cnki.1671-7236.2016.12.039

Abstract

Abstract:

Rabies is a lethal zoonotic infectious disease caused by rabies virus (RABV), which infected the central nervous system. The RABV glycoprotein exists on the surface of the virus particles, it is a major protective antigen which stimulate the body to produce the humoral immunity and cellular immunity;It is the identification of structure of the cell receptors;It plays an important role in the viral pathogenicity and tropism in the nerve, directly related to the virulence of virus.In this review,we summarized research progress of structure and function of RABV glycoprotein,and also reviewed the detection and evaluation of the neutralizing antibody. All these fundamental studies are important for the control and elimination of the RABV,to provide research basis for further revealing the biological function of RABV glycoprotein.

Key words: rabies; glycoprotein; neutralizing antibody

CLC Number:

WANG Meng-hang, ZHU Hong-wei, HE Min-hui, WEN Yong-jun, CHENG Shi-peng. Advances in Biological Function of Rabies Virus Glycoprotein[J]. , 2016, 43(12): 3349-3355.

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Advances in Biological Function of Rabies Virus Glycoprotein

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