禽呼肠孤病毒σB和σC蛋白二级结构及其细胞抗原表位预测

doi:10.16431/j.cnki.1671-7236.2016.11.011

Abstract

Abstract:

To predict the secondary structures and B-and T-cell epitopes of σB and σC proteins of avian reovirus（ARV),the secondary structures of ARV σB and σC proteins were predicted by DNAStar software and the Garnier-Robson,Chou-Fasman methods.B-and T-cell cell epitopes of σB and σC proteins were predicted by mutable parameters,including hydrophilicity,flexibility,surface probability and antigenicity.The analysis results showed that σB and σC proteins had few α-helix regions,meanwhile,compared with σB protein,σC protein possessed rather much β-sheet and turn regions,indicating σC protein exhibited more complex secondary structure.Furthermore,both σB and σC proteins had a few promising B cell and T cell epitopes,which would contribute to further explore the immune functions of σB and σC proteins,and provided a basis for development of ARV new type vaccine and therapeutic drugs.

Key words: avian reovirus; σB and σC proteins; secondary structure; epitope

CLC Number:

S852.65

HUANG Li, XIE Zhi-xun, XIE Li-ji, DENG Xian-wen, XIE Zhi-qin, FAN Qing, LUO Si-si, HUANG Jiao-ling, ZENG Ting-ting, ZHANG Yan-fang, WANG Sheng. Prediction of Secondary Structure and B-and T-cell Epitopes of σB and σC Proteins of Avian Reovirus[J]. , 2016, 43(11): 2880-2885.

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Prediction of Secondary Structure and B-and T-cell Epitopes of σB and σC Proteins of Avian Reovirus

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