m6A甲基化修饰调控产热脂肪组织的研究进展

doi:10.16431/j.cnki.1671-7236.2024.11.005

Abstract

Abstract: Excessive deposition of adipose tissue can lead to obesity and related metabolic diseases,and also directly affect the productivity and product quality of livestock and poultry.Therefore,how to regulate adipose tissue deposition is of great significance for safeguarding human health,increasing animal production performance and improving the quality of animal products.The thermogenic function of adipose tissue has become an area of great concern,which can regulate the body’s thermogenesis through the consumption of glucose,fatty acids,and other energy substances,so as to achieve the purpose of maintaining the energy balance of the body.N6-methyladenosine (m⁶A) modification,as a major epigenetic mark on RNA molecules,is activated in brown adipose tissue,adipose tissue browning and thermogenesis.The author outlines the thermogenesis of adipose tissue and mRNA m⁶A-related modification proteins,and focuses on the regulation of energy metabolism in thermogenic adipose tissue by mRNA m⁶A methylation modification,which is crucial for energy homeostasis,thermogenic adipose activation and metabolic diseases,so as to lay a foundation for the study of the specific thermogenic mechanism of thermogenic fat,and provide new ideas for the precise targeting and regulation of thermogenic mechanism of animal fat,and thus the regulation of animal production performance and product quality.

Key words: N6-methyladenosine (m⁶A); brown adipose tissue; beige adipose tissue; energy balance

CLC Number:

S852.23

FAN Yanyan, DU Jiawei, SUN Tianhao, FU Shaoyin, HE Xiaolong, ZHANG Lin, DA Lai, Terigele, WANG Liwei, HE Jiangfeng, LIU Yongbin, WANG Biao. Research Progress on Regulation of Thermogenic Adipose Tissue by m⁶A Methylation Modification[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(11): 4702-4710.

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Research Progress on Regulation of Thermogenic Adipose Tissue by m⁶A Methylation Modification

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Research Progress on Regulation of Thermogenic Adipose Tissue by m6A Methylation Modification

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Research Progress on Regulation of Thermogenic Adipose Tissue by m⁶A Methylation Modification