猪塞内卡病毒A研究进展

doi:10.16431/j.cnki.1671-7236.2024.10.042

Abstract

Abstract: Senecavirus A (SVA),a small RNA virus,has been causing vesicular lesions in pigs in recent years.It belongs to the genus Senecavirus in the family Picornaviridae.So far,research in the fields of genetic evolution,genome structure and function,pathogenesis,and epidemiology of SVA has achieved certain results,and various laboratory diagnostic methods have been established.In China,the range of SVA infection is quite extensive,predominantly presenting as asymptomatic latent infections,and co-infection with other pathogens are relatively common.At present,China has achieved significant technological improvements in the field of SVA detection.These advances include the application of several novel detection methods such as reverse transcription isothermal amplification PCR (RT-iiPCR),recombinase polymerase amplification (RPA),Real-time fluorescent reverse transcription recombinase-aided amplification (rRT-RAA),reverse transcription droplet digital PCR (RT-ddPCR),and Real-time reverse transcription loop-mediated isothermal amplification (RT-LAMP).However,considering that SVA is a novel RNA virus prone to mutation and recombination,there are no effective commercial vaccines or medications available against it currently,making the effective control and prevention of SVA a significant challenge.The current focus of SVA vaccine research is primarily on inactivated vaccines,but it also extends to subunit vaccines,live attenuated vaccines,nucleic acid vaccines,virus-like particle vaccines,and recombinant vector vaccines.For the antiviral treatment of infections caused by SVA,medications such as ribavirin or reboxetine mesylate can be utilized.Furthermore,extracts from traditional Chinese medicine and other natural products are being explored as potential antiviral agents.Here,the author is aimed to summarize the recent advance in researches on the epidemic distribution,etiology,epidemiology,differential diagnosis,as well as prevention and control of SVA,and to provide new perspectives and insights into strategies for SVA prevention and control.

Key words: Senecavirus A (SVA); etiology; epidemiology; differential diagnosis; disease prevention and control

CLC Number:

S852.65⁺1

HE Yuqian, LIJing, LIU Shuqing, ZHU Lijie, LIU Fuxiao, WANG Qi. Advance in Swine Senecavirus A[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(10): 4616-4625.

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Advance in Swine Senecavirus A

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