China Animal Husbandry and Veterinary Medicine ›› 2024, Vol. 51 ›› Issue (2): 614-623.doi: 10.16431/j.cnki.1671-7236.2024.02.018

• Genetics and Breeding • Previous Articles     Next Articles

Research Progress on the Primary Sex Determination Mechanisms in Mammals

JIANG Bowen1,2, LIU Guoshi1, ZHANG Lu1,2   

  1. 1. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;
    2. Advanced Science Center of Molecular Design and Breeding, China Agricultural University, Beijing 100193, China
  • Received:2023-08-18 Online:2024-02-05 Published:2024-01-29
  • Contact: 国家自然科学基金(32002181);中央高校基本科研业务费专项资金(2022TC143);科技创新-2030重大项目(2022ZD0401405)
  • Supported by:
    The project was supported by the National Key Research and Development Program of China (2019YFC1905301);National Natural Science Foundation of China (22078115,21776108,21690083,22008078).

Abstract: Sex determination in mammals is an important event that occurs during early embryonic development, and is crucial for the formation of an animal's reproductive capability.In recent years, with the development of high-throughput sequencing techniques, the transcriptome, proteome and spatial transcriptome analyze methods at the single-cell level and the cell lineage tracking and precise gene manipulation methods have made a great progress.All these techniques enabled the investigation of sex determination and gonadal development of mammals have made remarkable progress.Meanwhile, along with the continuous increase in the demand for sex-specific animals in livestock and poultry breeding, a series of breakthroughs have been made in the development of new sex sorting technologies based on sex determination mechanisms.With the elevated requirements of animal welfare, the application of postnatal sex sorting methods is limited, the sex sorting methods at sex determination stage shows great potential for application in the field of livestock and poultry production.The authors summarize the regulatory network of sex determination in mammals by analyzing the classical experiments related to sex determination and combining with the case reports of genetic defects clinical cases, and the entire regulatory network of mammalian primary gender determination is connected by studying the gender reversal phenomenon and gender specific differentiation process in gene expression manipulation experiments related to gender determination.In addition, this article traces the progress and development trend of sex sorting technologies utilizing gene editing techniques based on sex determination mechanisms.Thus, the review of mammalian sex determination mechanism in recent years will provide theoretical references for the innovative of livestock sex sorting technologies.

Key words: mammals; sex determination; molecular regulatory network; sex control

CLC Number: