雾化疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2024.03.032

Abstract

Abstract: In recent years,with the continuous development of mucosal vaccine and immunization technology,the reports of atomized vaccine and corresponding vaccination technology have gradually increased.Atomized vaccine is a kind of vaccine that makes liquid and solid immunogen into droplets (spray immunization) or aerosol particles (aerosol immunization) through atomizing device,and enters human and animal respiratory tract to induce the protective response.Atomized vaccine can induce mucosal immune response better,and at the same time,avoid the risk of disease transmission and pain caused by injection.Since the 1950s,the research on the spray immunization of Newcastle disease vaccine in chickens has opened the prelude of animal respiratory immunity.After that,the spray vaccination of infectious bronchitis vaccine was carried out.At present,the spray immunization of many poultry vaccines has been widely used.The research on aerosol immunization of swine vaccine started late and was more difficult.Since the end of 1970s,the corresponding aerosol immunization research has been carried out on classical swine fever vaccine,Actinobacillus pleuropneumoniae vaccine and Mycoplasma hyopneumoniae vaccine.Compared with animal vaccines,there are more reports on aerosol immunization of human vaccines,mainly focusing on measles vaccine,tuberculosis vaccine and influenza vaccine.Since 2019,the aerosol immunization of COVID-19 vaccine has developed rapidly,and it has been approved for emergency use in China.In this paper,the research status of atomized vaccines for animal and human is systematically stated,and the physical and chemical parameters,safety,tendency in vivo,local immune response in lung and protection effect of various atomized vaccines were summarized,and the future research on vaccine dosage forms,components,atomization generation devices,quality control,immunization program and effect evaluation were put forward.This review could provide a reference for the further research on respiratory mucosal vaccines.

Key words: atomized vaccine; aerosol; herd immunity; prevention and control of infectious diseases

CLC Number:

S859.79⁺7

WU Wei, HAO Fei, XIE Xing, FENG Zhixin. Research Progress on Atomized Vaccines[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 1203-1213.

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Research Progress on Atomized Vaccines

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