志贺菌对β-内酰胺类抗生素耐药机制研究进展

Abstract

Abstract: Shigella is the main pathogen of infectious diarrhea. In recent years, with the abuse of beta-lactam antibiotics, Shigella drug resistance has increased year by year. In addition, it shows the multi-drug resistance and cross-resistance. The resistance mechanisms is complex since it produces inactivated enzyme, changes action target and membrane permeability, and so on. Resistance genes are located in the plasmid, chromosome or transposable element, so it is easy to get spread. The study of resistance mechanism has a guiding significance for controlling the diseases caused by Shigella and new drug development.

Key words:

Shigella; resistance; betamso-bidi-font-family: 宋体" lang="EN-US">-lactam antibiotics

ZHU Zhen, WANG Jing, LIU Cui-cui, GUO Xiao, ZHANG Ji-yu, WEI Xiao-juan,ZHOU Xu-zheng. Research Progress of Shigella Antibiotic Resistance Mechanism against β-lactam[J]. .

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Research Progress of Shigella Antibiotic Resistance Mechanism against β-lactam

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