新型重配A（H7N9）流感病毒NA基因序列分析

Abstract

Abstract: The assay was aimed to analyze the molecular epidemiological character of influenza A (H7N9) virus in 2013. The complete genome sequences of NA of influenza virus strains from different discrete host sources downloaded from the GenBank were analyzed on genetic evolution by DNAStar software in this research. The results showed that, the neck amino acids of NA in influenza A (H7N9) virus in 2013 was deleted; HB site of NA took adaptive changes in certain degrees; the active site of proteases of HA with seven glycosylation sites was unchanged; the top ten high nucleotide homology strains with HA of A/Hangzhou/1/2013(H7N9) had isolated from poultry in five Asian countries, the nucleotide homology was more than 96%. It was not clear whether the NA gene of novel reassortment influenza A (H7N9) virus strains was avian-to-human transmission and needed further study.

Key words: influenza A virus; neuraminidase; genetic evolution analysis

LIU Yong-hong, ZHAO Li, DAI Yan-yan. Sequence Analysis of NA Gene of the Novel Reassortment Influenza A (H7N9) Virus[J]. .

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Sequence Analysis of NA Gene of the Novel Reassortment Influenza A (H7N9) Virus

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