硫酸头孢喹肟乳房注入剂对泌乳期奶牛的安全性研究

Abstract

Abstract: The aim of the experiment was to research the safety of cefquinome sulfate intramammary infusion for lactating cows.12 healthy lactating cows (6 were primiparous and 6 were multiparous) were selected to inject 1 peice of cefquinome sulfate intramammary infusion (dose:8 g:75 mg/piece) into four dairy regions of each cow for 3 times,and its interval of the administration was 12 h,and the evaluation indicators included the differences of clinical manifestation grade,daily yielding,somatic cells number and the changes of pathogen in dairy regions in milk before and after administration.The results showed that there were no significant differences in indicators all above before or after the treatment (P>0.05),which suggested that cefquinome sulfate intramammary infusion was safe to lactating cows when administrated according to the dosing regimen above.

Key words: cefquinome sulfate; lactation; cows; safety

CLC Number:

S823

YAN Xing, LIU Yi-ming, LU Yong-qiang, ZHANG Dao-kang, LIU Mao-lin, ZHANG Ning, WANG Tian-kun, GUO Jiang-peng, LI Xiu-bo. Safety Study on Cefquinome Sulfate Intramammary Infusion of Lactating Cows[J]. , 2014, 41(11): 278-282.

References

1 上官辉.如何控制牛乳体细胞超标[N].中国畜牧兽医报,2011-6-12.
2 中国兽药典委员会.中华人民共和国兽药典(2010年版)[M].北京:中国农业出版社,2010.
3 许莹,刘利锋,张洛,等.硫酸头孢喹肟冻干粉针安全性及稳定性试验[J].畜牧与兽医,2010,42(10):76～78.
4 何志强,孟娥,鲁云,等.奶牛乳房炎发病情况及危害[J].畜牧与饲料科学,2011,32(8):90～91.
5 吴伟.奶牛乳房炎的预防及治疗措施[J].中国畜牧杂志,2007,43(18):54～58.
6 李会,孙志文,汤树生,等.复方阿莫西林乳房注入剂治疗临床型奶牛乳房炎的疗效观察[J].中国兽医杂志,2012,48(3):71～74.
7 孟庆娟,冯士彬,李志明,等.中药复方灌注剂治疗奶牛乳房炎的药效与应用安全性研究[J].湖北农业科学,2011,50(9):1847～1849.
8 岳永波,吴好庭.猪肌肉注射硫酸头孢喹肟注射液的安全性试验[J].畜牧与兽医,2008,40(6):76～78.
9 俞吉杰,余祖功,赵杰,等.HPLC法测定硫酸头孢喹肟冻干粉针中硫酸头孢喹肟含量[J].畜牧与兽医,2008,40(9):31～34.
10 高金兴.头孢喹肟在奶牛中残留的HPLC检测及消除规律研究[D].扬州:扬州大学,2009.
11 萧惠来.VICH兽药靶动物安全性研究指导原则概述[J].中国兽药杂志,2009,43(12):33～37.
12 蒋春茂,周新民,周广生,等.奶牛乳房炎研究进展[J].中国畜牧兽医,2004,31(5):34～38.
13 Heringstad B,Klemetsdal G,Ruane J.Clinical mastitis in Norwegian cattle:Frequency,variance components,and genetic correlation with protein yield[J].Journal of Dairy Science,1999,82(6):1325～1330.
14 Murphy S P,Erwin M E,Jones R N.Cefquinome (HR ⅢV) in vitro evaluation of a broad-spectrum cephalosporin indicated for infections in animals[J].Diagnostic Microbiology and Infectious Disease,1994,20(1):49～55.
15 Pengov A,Ceru S.Antimicrobial drug susceptibility of Staphylococcus aureus strains isolated from bovine and ovine mammary glands[J].Journal of Dairy Science,2003,86(10):3157～3163.
16 Rose M,Wissler R,Zschiesche E,et al.Efficacy and tolerance of a new cephalosporin,cefquinome,formulation for treatment of bacterial respiratory diseases of pigs[J].Tierartliche Praxis Ausgabe Grossiere Nuztiere,2000,28(6):331～336.
17 Sachimmel D.Establishment of pigs herds free form pneumonia by immunization and cefquinome treatment[J].Berliner Und Munchener,1992,105(11):378～380.
18 Shpigel N Y,Levin D,Winkler M.Efficacy of cefquinome for treatment of cows with mastitis experimentally induced using Escherichia coli[J].Journal of Dairy Science,1997,80(2):318～323.
19 Thomas E,Thomas V,Wilhelm C.Antibacterial activity of cefquinome against equine bacterial pathogens[J].Veterinary Microbiology,2006,115:140～147.

[1]	HU Honglian, LI Chao, CHEN Liqing, SONG Liwen, ZHAO Meng, ZHANG Jianxia, WANG Dian, GAO Min. Effects of Dietary β-carotene Supplementation on Lactation Performance, Blood Routine,Serum Biochemical and Immune Indexes of Dairy Cows during the Lactating Peak Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1375-1384.
[2]	ZHANG Xinke, ZHU Xuedan, CHEN Yun, ZHANG Shouquan. Research Progress on Bone Mineral Density and Its Relationship with Mammalian Production [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1422-1433.
[3]	LI Yuanyuan, YANG Na, TENG Da, HAO Ya, MA Xuanxuan, MAO Ruoyu, WANG Jianhua. Preparation and Evaluation of Efficacy and Safety of Shengtaicin Post-medicated Bath Solution for Dairy Cow [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1617-1631.
[4]	LI Dan, ZHANG Haisen, WANG Yiqun, GAO Dengke, ZHAO Hongcong, LI Chao, JIN Yaping, CHEN Huatao. Eukaryotic Expression Vector Construction,Bioinformatics and Tissue Expression Profiles Analysis of CRY1 Gene in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 870-881.
[5]	KONG Weiyi, WANG Feifei, YUE Kang, QIN Junjie, ZHU Hao, GUO Yansheng. Effect of Guiqi Yimu Oral Liquid on Plasma Metabolites in Postpartum Dairy Cows Based on UPLC-MS/MS Metabolomics Technology [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 913-923.
[6]	HE Yue, WANG Hui, CHEN Ruipeng, YU Zhixue, TANG Xiangfang, GUO Yuming, XIONG Benhai. Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 827-837.
[7]	ZENG Zhiqin, LOU Wenqi, XU Jingyi, MA Yehua, ZHANG Yongfu, REN Xiaoli, CHEN Shaokan, YAN Lei, GUO Gang, ZHANG Zhen, WANG Yachun. Analysis of Impact Factors and Phenotype Prediction for Transforming Progesterone Concentration in Chinese Holstein Cows During Lactation [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 186-197.
[8]	FU Qi, YU Houmo, ZHANG Hailiang, XU Jingyi, HU Yuyang, DUAN Yujiao, ZHOU Yueling, HUANG Siqi, ZHANG Yayi, GUO Gang, YU Ying, WANG Yachun. Influencing Factors Analysis and Genetic Parameters Estimation of Muzzle Width in Holstein Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 230-237.
[9]	AN Xiaopeng, LIU Nan, HU Zhengjiamei, HU Jincao, XU Xiaolong, ZHANG Lei, SONG Yuxuan. Comparative Analysis of Lactation Performance of East Friesen Sheep, Hu Sheep and East Friesen-Hu Hybrid Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 238-245.
[10]	SUN Yu, ZHANG Hao, LI Changyang, TAO Yanzi, WANG Qiuju. Isolation,Identification and Biological Characteristics of Antioxidant Bacillus from Cattle [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 359-367.
[11]	YANG Chaohui, MA Xuelian, WANG Fan, YI Pengfei, WU Jing, FENG Mengdi, CHEN Yuzhu, SUN Yawei, WUMAIERJIANG·Yahefu, WANG Sheng, XU Jianbiao, ZHONG Qi, ZHOU Zhenyong, YAO Gang. Determination of Colostrum Yield and Quality of Angus Cows and Evaluation of Passive Immunity Effect of Newborn Calves [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3353-3361.
[12]	JI Haonan, GAO Qing, CHANG Yao, ZHANG Hailiang, WU Hongjun, CHAI He, YU Ying, WANG Yachun. Analysis of Influencing Factors on Milking Speed Indicators in Holstein Cows [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3475-3483.
[13]	SHAO Mingzhu, ZHAO Yunqing, LI Songli, HOU Shaohua, ZHANG Yanying. Isolation and Identification of Escherichia coli from Dairy Cows in Hebei Province and Its Pathogenicity and Antibacterial Effect of Chinese Herbal Medicine in vitro [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3683-3691.
[14]	CAI Meng, ZHU Xiaoyan, WANG Mengling, LIU Zihao, XIONG Benhai, YANG Liang. Effect of Staphylococcus aureus on Exosome Characterization of Mammary Epithelial Cells in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 3091-3098.
[15]	XU Xiaoling, BAI Jiahua, XIAO Linli, QIN Yusheng, SONG Yuqing, LIU Yan. Effects of Compound Additives on the Quality and Conception Rate of Dairy Cows Thawed Sex Controlled Frozen Semen [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2654-2660.

Safety Study on Cefquinome Sulfate Intramammary Infusion of Lactating Cows

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments