超高效液相色谱串联四级杆/飞行时间质谱仪鉴定喹赛多在鸡体内代谢研究

Abstract

Abstract: In this study,we identified the metabolites of cyadox in vivo produced by chicken using ultra performance liquid chromatography/quadruple time of flight tandem mass spectrometry(UPLC-Q-TOF MS).Besides,it had been viewed that proposed metabolic pathways of cyadox in vivo of chicken. Animals were administered a single of cyadox (800 mg/kg) by oral gavage.We used UPLC-Q-TOF MS to analyze chicken feces, collected before and after the experiment, which were simple pretreatment. A total of fifteen metabolites were identified after the collected data processed by the software of Metabolynx^xs . This experimental results showed that cyadox occurred widely metabolism in vivo of chicken.

Key words: cyadox; UPLC-Q-TOF MS; chicken; metabolism in vivo

CLC Number:

S859.84

YANG Shu-peng, WANG Ying, LI Yan-shen, SHEN Jian-zhong, YANG Jing, ZHANG Su-xia. Identification of the Metabolites of Cyadox in vivo Produced by Chicken Using Ultra Performance Liquid Chromatography/Quadruple Time of Flight Tandem Mass Spectrometry[J]. , 2013, 40(3): 11-18.

References

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Identification of the Metabolites of Cyadox in vivo Produced by Chicken Using Ultra Performance Liquid Chromatography/Quadruple Time of Flight Tandem Mass Spectrometry

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