基于防突变浓度的新型药动学-药效学-突变选择窗同步模型在临床用药上的指导作用

Abstract

Abstract: Development history of pharmacokinetic/pharmacodynamic(PK/PD) model for antimicrobial drugs was reviewed in the present article, including the important role of new PK/PD model in inhibition bacterial resistance mutation, intruction in the rational design of drug regimen and new drug investigation. In addition, problems of clinical application of PK/PD model were also discussed.

Key words: PK/PD model; mutant selection window; resistance; rational drug administration

CLC Number:

S859

LIAO Xue-ling, ZHANG Bing-xu, DING Huan-zhong. Instruction Function in Drug Administration on the New PK-PD-MSW Modeling Based on Mutant Prevent Concentration[J]. , 2013, 40(1): 199-203.

References

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Instruction Function in Drug Administration on the New PK-PD-MSW Modeling Based on Mutant Prevent Concentration

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