副流感病毒基因工程研究进展

Abstract

Abstract: The parainfluenza virus is a nonsegmented negative-strand RNA virus (NNSV),according to the genetic type, it is divided into 1,2,3,4 and 5 types, the fourth type can be divided into 4a and 4b subtypes, five types have bits of cross immunity. Biological characteristics and structures of each type are similar.The host range of parainfluenza virus is wide, it can infect human,canine,cattle and many others animal. The parainfluenza virus has a number of feature that make them attractive candidates as live virus vectors. The vectors can express foreign antigen, as a new vaccine by the reverse genetic system. This review will focus on the genetic engineering research development of parainfluenza virus as virus vectors, including antigenic, genetic structure, biological characteristics and so on.

Key words: parainfluenza viruse; gene; research progress

CLC Number:

S852.65^＋9.5

CAO Li, SHI Xin-chuan, GAO Wei-fan, WEN Yong-jun. Reaserch Progress on Parainfluenza Virus Genetic Engineering[J]. , 2013, (5): 185-189.

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Reaserch Progress on Parainfluenza Virus Genetic Engineering

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