Abstract: Paracetamol succinate(AP-S) was synthesized from paracetamol and succinic anhydride by using 4-dimethylaminopyridine (DMAP) as catalyst and acetone as solvent. AP-S yield was selected as the main index, the synthetic technology was optimized by an orthogonal design including factors such as raw material monomer ratio, solvent dosage, reaction temperature, reaction time and so on. Characteristics of AP-S were identified by chemical identification, pH test, melting point test, IR, UV and HPLC. In result, the features of resultants was consistant with AP-S. The optimized synthetic technology was succinic anhydride and paracetamol monomer ratio 2∶1, catalyst 0.15 g, acetone 30 mL, temperature 60 ℃ and time 6 h, and the yield was 81.7%.

Key words: paracetamol succinate; DMAP; synthesis technology; characteristics