Abstract: Telomerase is capable of maintaining telomere lengths by balancing out the gradual loss of telomeric sequences that occurs during cell division. It plays an important role in regulating life span of animal cells.In order to improve cell culture efficiency in vitro,a great deal of research has been attempted. And the way of increasing the activity of telomerase is considered to be one of the most effective approaches to improve cell culture efficiency. This article will make a brief summary of these recent achievements.

Key words: mammalian; oocyte; culture system; activity of telomerase; regulation