›› 2012, Vol. 39 ›› Issue (11): 52-56.

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Progress in Development of Genetic Engineering Vaccines against Infectious Bovine Rhinotracheitis

XU Qiong1, HE Yu-qian2, WU Hai-yan3   

  1. 1. Qingdao Entry-exit Inspection and Quarantine Bureau, Qingdao 266001, China;
    2. Qingdao Center for Animal Disease Control & Prevention, Qingdao 266071, China;
    3. Qingdao Animal Health Inspection Institute, Qingdao 266071, China
  • Received:2012-04-09 Online:2012-11-20 Published:2012-11-22

Abstract: Infectious bovine rhinotracheitis (IBR) is a highly contagious, infectious disease that is caused by bovine herpes-virus-1(BHV-1). In addition to causing respiratory disease, this virus can cause conjunctivitis, abortions, encephalitis, andgeneralized systemic infections. IBR was originally recognized during the early 1950’s in Colorado feedlots. There is no direct treatment for the infection and the best way to control IBR is to vaccinate before a disease outbreak occurs. Nowadays, conventional IBR vaccines have been, and still are, routinely used in many countries, the glycoprotein E (gE)-deleted vaccines, either as a live or as a inactivated vaccine, have been commercialized in the European Union. In this review, we discussed the progress in development of gene-deleted vaccine, subunit vaccine, viral vector vaccine and DNA vaccine.

Key words: infectious bovine rhinotracheitis; gene-deleted vaccine; subunit vaccine; viral vector vaccine; DNA vaccine

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