新城疫病毒囊膜糖蛋白生物学特性的研究进展

Abstract

Abstract: Newcastle disease is one of the most serious infectious disease of poultry in present worldwide. Newcastle disease virus(NDV) has a negative-sense,single-stranded RNA genome, encoding six structural proteins that NP,P,M,F,HN and L,which are located in the peplos both F and HN glycoproteins are the most important. F protein with the role of the virus envelope and host cell membrane fusion, resulting in the virus penetrates the host cell membrane,is key factor to determine the virulence. HN protein with two active of hemagglutinin and neuraminidase, which has an important role to NDV infection cells. The two glycoproteins are not only play a decisive role to the virulence and pathogenicity of NDV,but also introduce protective antibody. The paper provides a review of the structure and function of this two proteins.

Key words: NDV; F protein; HN protein; biological characteristics

CLC Number:

S858.32

TIAN Xian-li;NING Hong-mei;YIN Mei;YUE Feng;WEI Ji-tao. Advances of Research on Biological Characterization of Envelope Glycoproteins in Newcastle Disease Virus[J]. , 2011, 38(8): 189-192.

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Advances of Research on Biological Characterization of Envelope Glycoproteins in Newcastle Disease Virus

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