Abstract: To compared anesthetic effects of ketamine combined with thiopentalum natricum on Wuzhishan minipigs. 40 healthy minipigs were divided into two groups: anesthesia by ketamine (n=20,group 1) or ketamine combined with thiopentalum natricum (n=20,group 2). All minipigs underwent muscular or venous injection with these chemicals. It was found that anesthesia of group 2 maintained (198.0±32.7) min,anesthesia of group1 maintained (104.0±17.3) min,and group 2 showed better anaesthesia effect. Furthermore,the combined anesthetization could improve the anesthetic effect: increase muscular relaxation,do not interfere with respiration and cycle system,and show prolonged and more stable anesthesia with quick resuscitation. Thus,ketamine combined with thiopentalum natricum appears to be a perfect method for the prolonged surgery of experimental minipigs.

Key words: Ketamine; thiopentalum natricum; anesthesia; Wuzhishan minipigs