不同麻前给药配合乳化七氟烷对矮马肾素-血管紧张素-醛固酮系统及无创血压影响的对比

doi:10.16431/j.cnki.1671-7236.2021.02.039

Abstract

Abstract: The aim of this study was to compare the effects of different pre-anesthesia administration regimens combined with emulsified sevoflurane on non-invasive blood pressure and renin angiotensin aldosterone system (RAAS).Ten semi-wild ponies were randomly divided into two groups,KFXES and KFDBES.The ponies were anesthetized (ketamine,Jingsongling and fentanyl were used in KFXES group,while ketamine,butorphanol,dexmedetomidine and fentanyl were used in KFBES group) by intramuscular injection.The ponies maintained spontaneous respiration and maintained anesthesia for 2 h by intravenous infusion of 6% emulsified sevoflurane at constant speed.Before administration,the basic physical signs of ponies were recorded under normal condition,and the vital signs were continuously recorded for more than 2 hours after anesthesia.Noninvasive blood pressure was monitored at 0,30,60,90 and 120 min,and blood samples were taken simultaneously to detect the concentrations of renin,angiotensin,aldosterone and other factors in plasma.The results showed that,in the course of the experiment,the blood pressure of the ponies in KFXES group was significantly different from that before the test (P<0.05).At 0-60 min,the inhibition to RAAS between two groups had no significant difference (P>0.05).When the anesthesia time was more than 90 min,the inhibition of KFXES group on RAAS system was significantly weaker than that of KFDBES group (P<0.05).Therefore,ketamine,fentanyl,butorphanol and dexmedetomidine combined emulsified sevoflurane had better blood pressure stability than ketamine,Jingsongling and fentanyl combined emulsified sevoflurane,and had a greater impact on RAAS after 90 min.The results of this study could provide data support and direction guidance for the optimization of anesthesia method or dose of pony.

Key words: pony; anesthesia; renin-angiotensin-aldosterone system (RAAS); emulsified sevoflurane

CLC Number:

S859.79⁺1

DU Yuanyi, ALANCIA CAROL Cliftion, LIU Na, FAN Yuying, JIA Haotian, GE Ruidong, LI Xiuyun, ZOU Ximing, LIU Yun. Comparison of the Effects of Different Premedication Combined with Emulsified Sevoflurane on Renin-angiotensin-aldosterone System and Noninvasive Blood Pressure in Pony[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(2): 763-771.

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Comparison of the Effects of Different Premedication Combined with Emulsified Sevoflurane on Renin-angiotensin-aldosterone System and Noninvasive Blood Pressure in Pony

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