动物GH/IGF-Ⅰ轴调控机制的研究进展

›› 2011, Vol. 38 ›› Issue (10): 50-54.

• 生理生化 • Previous Articles Next Articles

Advances on the Regulation Mechanism of Growth Hormone/IGF-Ⅰ Axis

GU Zhi-liang¹, WANG Hui-juan^1,2, YU Jian-feng¹

1. College of Life Science and Food Technology,Changshu Institute of Technology,Changshu 215500, China;2. College of Basic Medicine and Life Science,Soochow University,Suzhou 215123, China

Received:2011-02-21 Revised:1900-01-01 Online:2011-10-20 Published:2011-10-20

Abstract

Abstract: The growth axis is a neuroendocrine system, which is composed of series of hormones and their receptors from the hypothalamus-pituitary-target organ in vivo of animals. Increasing the GH and IGF-Ⅰ levels in the growth axis, to promote weight gain, feed conversion rate and improve meat quality, which is a new approach of animal growth regulation. GH mediated by IGF-Ⅰ regulates animal growth and cell differentiation. We will discuss the constitution and function of GH/IGF-Ⅰ axis, and mechanism of growth hormone regulation of IGF-Ⅰ expression in this review.

Key words: growth hormone; IGF-Ⅰ gene; regulation of gene expression

CLC Number:

GU Zhi-liang;WANG Hui-juan;YU Jian-feng. Advances on the Regulation Mechanism of Growth Hormone/IGF-Ⅰ Axis[J]. , 2011, 38(10): 50-54.

[1]	SUN Qingshuai, YAN Weidong, LI Chang, WU Hao, LI Changchun, HE Qigai. Effect of PCV3 on the Expression of Growth-related Hormones and Functional Genes in Piglets [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1041-1047.
[2]	CAO Yue, LI Dabiao. Regulatory Effects of Hormones on Milk Fat Synthesis in Bovine Mammary Epithelial Cells [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(8): 2778-2786.
[3]	SU Jun, LIU Man, WANG Jigui, SUN Yan, LIU Weiquan. Prokaryotic Expression and Specific Antiserum Preparation of Mink Growth Hormone [J]. , 2018, 45(4): 866-872.
[4]	LIU Tian, GONG Qiang, LI Xiang-zi, GAO Qing-shan, YAN Chang-guo. Effects of Castration at 6 Months Old on Growth Performance, Testosterone and Growth Hormone Levels in Blood of Yanbian Cattle [J]. , 2017, 44(10): 2937-2943.
[5]	YU Jian-feng, HE Sai, JIN Ze-kai, ZHOU Huan-qing, DONG Xiao-min, GONG Dao-qing, GU Zhi-liang. Expression,Purification and Biological Activity Identification of Chicken Growth Hormone in Pichia pastoris [J]. , 2016, 43(11): 2970-2975.
[6]	SONG Jia-zhe, LI Wen-zhe, XUE Kai. Research Progress on Molecular Pathways of Mammalian Ovary Follicle Development [J]. , 2015, 42(5): 1259-1267.
[7]	TAO Xuan, GU Yi-ren, LIANG Yan, YANG Xue-mei, ZENG Kai, CHEN Xiao-hui, YANG Yue-kui, ZHONG Zhi-jun, LV Xue-bin. Study on Developmental Changes of Growth Hormone (GH) and Growth Hormone Releasing Hormone (GHRH) in Serum of Pigs [J]. , 2015, 42(12): 3288-3293.
[8]	LI Yu-meng, HONG Pan, LAN Hai-nan, ZHENG Xin. Research Progress on Mechanism of Growth Hormone Promoting Cell Growth [J]. , 2015, 42(1): 147-152.
[9]	YANG Yan-hong，FU Zhi-ling，LIU Yu，LAN Hai-nan，ZHANG Hui，WU Min，MA Si-hui,LI Yu-meng，LI Yan-qiang, ZHENG Xin. Functional Characterization of Anti-growth Hormone Receptor Monoclonal Antibody [J]. , 2014, 41(2): 25-28.
[10]	WU Tian-cheng, LAN Hai-nan, MA Si-hui, YANG Huan, LI Yu-meng, HONG Pan, LI Yan-qiang, LIU Hai-yan, ZHANG Xiao-yin, ZHENG Xin. Research Progress on Signal Transduction Mechanisms Underlying Growth Hormone Receptor Action [J]. , 2014, 41(12): 186-189.
[11]	SHI Lin, LIN Shuai, ZHOU Dong-qing, SUN Yan-jun, WANG Zhi-qiang. Construction and Identification of Eukaryotic Expression Vector of Porcine Growth Hormone Secretagogue Receptor Gene [J]. , 2014, 41(1): 43-46.
[12]	YANG Yan-hong, FU Zhi-ling, LAN Hai-nan, LI Wei, LIU Yu, GUO Feng, ZHANG Hui, CUI Huan-zhong, ZHAO Xue, ZHENG Xin. Research Progress on the Mechanism of Growth Hormone-activated Receptor [J]. , 2013, 40(10): 148-151.
[13]	LIU Yu, LAN Hai-nan, LI Wei, YANG Yan-hong, FU Zhi-ling, MA Si-hui, WU Tian-cheng, GUO Feng, ZHAO Xue, ZHANG Hui, CUI Huan-zhong, WU Min, YANG Huan, LI Yu-meng, HONG Pan, ZHENG Xin. Isolation and Culture of Rat Primary Hepatocytes, and Identification of its Membrane Receptor [J]. , 2013, 40(10): 144-147.
[14]	PAN Long, BU Deng-pan, SUN Peng, ZHOU Ling-yun. The Structure and Regulation of Growth Hormone on Dairy Lactation [J]. , 2013, 40(1): 125-130.
[15]	LIU Chang;ZHAO Feng;LI Qing-zhang. Influence of Different Hormone and Cytokine Related Lactation on the Proliferation of Mammary Epithelial Cells of Dairy Cow [J]. , 2012, 39(5): 102-106.

Advances on the Regulation Mechanism of Growth Hormone/IGF-Ⅰ Axis

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments