黄体酮聚乳酸微球制备及其体外释药特性研究

›› 2011, Vol. 38 ›› Issue (10): 228-231.

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Preparation and in vitro Release Property of Polylactic Acid Microspheres Containing Progesterone

GAO Hao¹, FANG Bing-hu¹, LIU Ya-hong¹, CHEN Chao-xi², TANG Yong-yong¹, CHEN Jian-xin¹

1. College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China;2. Department of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China

Received:1900-01-01 Revised:2011-04-08 Online:2011-10-20 Published:2011-10-20

Abstract

Abstract: To prepare progesterone PLA microspheres by emulsification solvent evaporation process and investigate the characteristics of progesterone PLA microspheres in vitro release.Progesterone PLA microspheres formulation and preparation parameters were investigated and established basing on the entrapment efficiency and content of the drug. Seven factors were selected to establish the optimal conditions. The morphology of microspheres was characterized by SEM. UV spectrometry was used to determine the entrapment efficiency, the drug loading and release property in vitro. The progesterone PLA microspheres were smooth, round, well dispersed and consistent diameters. The entrapment efficiency of the progesterone PLA microspheres was (80.60±1.00)%, drug loading was (10.63±0.05)%,cumulative release in 7 days was 53.41% in vitro.The progesterone PLA microspheres had distinct slow-release effect and could prolong the medicine action time.

Key words: progesterone; polylactic acid microspheres; in vitro release

CLC Number:

S859.7

GAO Hao;FANG Bing-hu;LIU Ya-hong;CHEN Chao-xi;TANG Yong-yong;CHEN Jian-xin. Preparation and in vitro Release Property of Polylactic Acid Microspheres Containing Progesterone[J]. , 2011, 38(10): 228-231.

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Preparation and in vitro Release Property of Polylactic Acid Microspheres Containing Progesterone

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