›› 2015, Vol. 42 ›› Issue (2): 493-497.doi: 10.16431/j.cnki.1671-7236.2015.02.040

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Effect of Progesterone on Immune Tolerance during Early Pregnancy in Ruminant

WANG Yong-xiang1,2, YANG Ling1, BI Jiang-hua2, LI Shu-jing2   

  1. 1. College of Agriculture, Hebei University of Engineering, Handan 056021, China;
    2. Shijiazhuang Tianquan Dairy Cattle Co., Ltd., Shijiazhuang 050051, China
  • Received:2014-07-15 Online:2015-02-20 Published:2015-02-13

Abstract: It plays an important role for the endocrine and immune function of progesterone in pregnant establishment and maintenance during early pregnancy in ruminants.At present,there is a high rate of embryonic loss and early abortion in ruminant, which plagues the farmers,while the mechanism of progesterone-induced immune tolerance is not well understood.In this review,the effect of progesterone on immune tolerance is introduced during early pregnancy in ruminants,including the source of the progesterone,mode of progesterone action,effect of progesterone on organism immunity,progesterone-mediated immune tolerance.This will provide a theory reference for the study of immune tolerance induced by progesterone during pregnancy in ruminants.

Key words: progesterone; early pregnancy; immune tolerance

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