Abstract:

The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics require the discovery of new therapeutic approaches. Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit of toxin function， bacterial toxin delivery， the regulation of virulence expression， adhesion and so on. These drugs can represent a new paradigm for the clinicians to prevent and treat infectious diseases more effectively, make up for existing inadequacies of anti-infection drugs and develop a new way for anti-infective drugs, while they do not affect the survival of bacteria directly.

Key words: anti-infectious medicine; bacterial virulence; targeted therapy