Abstract: In order to make clear the safety of Shegan Mahuang Dilong powder and provide date support for the clinical medication, 120 21-day-old Sanhuang broilers were randomly divided into four groups including 3, 6, 12 times dose group and control group,every group had thirty broilers. When the chickens were 21 and 35 days old, according to the chickens’ average weight of each group, the drug of different doses was fed to the chicken and the drug was fed for 2 weeks continuously. When the chickens were 35 and 49 days old, 10 chickens in each group were randomly selected for blood collection and necropsy. Then the parameters of kidney and liver functions were measured and the pathological examination of hearts, livers, spleens, lungs and kidneys was carried out. The results showed that there was no regularity between the serum alanine aminotransferase activity, creatinine concentration and drug’s dosages of each group while the levels of albumin and urea had no significant differences compared with the control group(P>0.05). After administration, the chickens’ hearts, livers, spleens, lungs and kidneys were no significant differences in the performance of normal in all groups. The results showed that Shegan Mahuang Dilong powder had small interference to kidney and liver functions of the chickens. And there were no toxic effects to the heart, liver, spleen, lungs and kidney after pathological examination. So it was a low toxic and safe traditional Chinese medicine preparation which was suitable for clinical use.

Key words: Shegan Mahuang Dilong powder; chicken; kidney and liver function; pathological examination