Abstract: Somatic cell nuclear transfer is currently one of the hot spots in the area of biotechnology. The research of mice somatic cell nuclear transfer has tremendous value because of the clear genetic background, short breeding cycle and lower breeding cost of mice. This paper reviews the brief history of mice somatic cell nuclear transfer, discussed its main methods,summarized the factors affecting its efficiency and its molecular mechanism, and looks forward to the future of mouse somatic cell nuclear transfer.

Key words: mice; somatic cell; nuclear transfer; experimental animal