哺乳动物性晚熟相关基因的研究进展

›› 2009, Vol. 36 ›› Issue (2): 86-89.

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Advances on Related Genes with Delayed Puberty in Mammals

FENG Tao1, DI Ran2, CHU Mingxing2, ZHANG Yingjie1，3

（1.College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;2. The Key Laboratory of Domestic Animal Genetic Resources and Germplasm Innovation of CAAS, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;3. College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China）

Received:1900-01-01 Revised:1900-01-01 Online:2009-02-20 Published:2009-02-20
Contact: CHU Ming-xing

Abstract

Abstract: Sexual maturation of humans and mammals was driven by an intermittent discharge of gonadotropinreleasing hormone (GnRH) generated by a network of hypothalamic neurons known as the GnRH pulse generator. Reproductive disorder will present once GnRH release was suppressed or destroyed, which will result in hypothalamic hypogonadism. As for humans, this disorder presents azoospermatism and amenorrhea resulted from hypoevolutismus and sex hypoplasia. Animals affected by hypothalamic hypogonadism present puberty delay and reproductive capacity degression. Mutations of the genes encoding gonadotrophins and their receptors may cause delayed puberty. This review briefly introduced the relationships between GPR54, GnRH/GnRHR, FSH/FSHR, LH/LHR genes and delayed puberty in mammals.

Key words: delayed puberty; gene; mutation

CLC Number:

Q953⁺.3

FENG Tao;DI Ran;CHU Mingxing;ZHANG Yingjie;. Advances on Related Genes with Delayed Puberty in Mammals[J]. , 2009, 36(2): 86-89.

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Advances on Related Genes with Delayed Puberty in Mammals

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