中药防控产肠毒素大肠杆菌感染仔猪腹泻的研究进展

doi:10.16431/j.cnki.1671-7236.2024.12.037

Abstract

Abstract: Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) seriously affects the health of piglets,which is an important cause of death of piglets,and brings huge economic losses to pig breeding industry.The main virulence factors of ETEC are enterotoxin and adhesin.Enterotoxin is mainly divided into heat-stable enterotoxin and heat-labile enterotoxin,which act on the surface of small intestinal epithelial cells in different ways,causing water and electrolyte accumulation and metabolic disorders in small intestine,resulting in diarrhea of piglets,while adhesin promotes the colonization of ETEC in small intestinal epithelial cells of piglets.The current vaccines only include part of fimbrial adhesin and enterotoxin,and the immune effect is not comprehensive and lacks broad spectrum.At present,the effect of traditional Chinese medicine in clinical application is good,which can greatly improve the survival rate of infected piglets,inhibit the growth of ETEC and the expression of virulence genes,alleviate the inflammatory response,reduce intestinal damage,improve the immunity of infected piglets,regulate the balance of intestinal microorganisms caused by ETEC infection,and regulate the intestinal chemical barrier of piglets，to prevent and control ETEC infection from various aspects.Under the background of total forage prohibition,consumers are increasingly favoring green and non-resistant pig products,and veterinary Chinese medicine provides new ideas and strategies for the clinical prevention and control of piglet diarrhea disease. Therefore,the author summarized the pathogenic mechanism of ETEC invasion into the intestinal tract of piglets and the application and therapeutic effect of Chinese medicine in the treatment of this disease.

Key words: enterotoxigenic Escherichia coli (ETEC); traditional Chinese medicine; diarrhea; enterotoxin

CLC Number:

S858.292

YANG Zhi, WANG Yuxuan, WANG Zhiwen, LU Hongde, WANG Luhao, HE Zhiyuan, DONG Hong. Research Progress on Prevention and Control of Diarrhea of Piglets Infected with ETEC by Traditional Chinese Medicine[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(12): 5507-5517.

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Research Progress on Prevention and Control of Diarrhea of Piglets Infected with ETEC by Traditional Chinese Medicine

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