猪流行性腹泻病毒逃避宿主干扰素抗病毒作用机制的研究进展

doi:10.16431/j.cnki.1671-7236.2019.07.026

Abstract

Abstract:

Porcine epidemic diarrhea virus (PEDV) is a globally distributed alpha coronavirus,which can cause epidemic diarrhea in piglets.Porcine epidemic diarrhea outbreak will bring huge economic losses to the breeding industry.Type Ⅰ interferon (IFN-Ⅰ) is a key mediator of innate antiviral responses during viral infection.Most coronaviruses produce strategies to limit IFN response by limiting IFN production and activation of IFN responses.However,the molecular mechanism by which PEDV antagonizes the antiviral effect of IFN is not fully understood.After the pig is infected with PEDV,the body's innate immunity is not effective against PEDV.PEDV escapes host innate immunity by limiting or blocking the function of IFN and hiding its pathogen-associated molecular patterns (PAMP).In this process,structural and non-structural proteins of PEDV and some proteases play a key role.The nucleocapsid (N) protein can inhibit the production of IFN-Ⅰ and help the virus escape the antiviral natural immunity of the body.Papain-like protease blocks the natural immune signaling pathway by deubiquitinating enzyme activity.PEDV also evades host innate immunity by blocking the production of IFN-Ⅰ induced by double-stranded RNA (dsRNA).These studies provide a theoretical basis for understanding the role of IFN in the pathogenesis of PEDV and the mechanism by which PEDV escapes IFN against viruses,and help to understand the relationship between the virus and the host's innate immunity,it also provides a theoretical basis for the prevention and treatment of PEDV and the development of PEDV vaccine.

Key words: porcine epidemic diarrhea; escape; interferon (IFN); innate immune

CLC Number:

S852.651

ZHU Hongxiao, WANG Qiuxia, LI Peng, OU Changbo, HU Huilong, WEI Xiaobing, ZHANG Xiulin, LIU Xingyou. Research Progress on Mechanism of Porcine Epidemic Diarrhea Virus Evading the Antiviral Effect of Host Interferon[J]. , 2019, 46(7): 2096-2102.

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Research Progress on Mechanism of Porcine Epidemic Diarrhea Virus Evading the Antiviral Effect of Host Interferon

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