骨形态发生蛋白15基因与绵羊繁殖性能关系的研究进展

doi:10.16431/j.cnki.1671-7236.2017.08.025

Abstract

Abstract:

To further optimize and promote the reproductive performance of the domestic level on sheep breeding,this paper focus on bone morphogenetic protein 15 (BMP15) gene, which is a major gene of reproductive traits in recent research,and combing its research progress, direction and pathway. In this paper,its signal transduction, mechanism, performance of sheep breeding and effect of production research in domestic practice were discussed. Totally,the domestic research of BMP15 gene is not deep enough in the mechanism of action, or in the marker assisted selection of applications filed that needs more research scholars to participate in this work. Meanwhile to provide reference of the research of BMP15 gene and marker assisted selection of domestic sheep.

Key words: BMP15 gene; sheep; reproductive performance

CLC Number:

S813.3

CHENG Li-fen, JI Ai-guo, WANG Qing-xiang. Research Progress on the Relationship Between BMP15 Gene and Reproduction Performance of Sheep[J]. , 2017, 44(8): 2392-2397.

References

[1] 侯振平, 蒋思文. 骨形成蛋白15基因的研究进展[J]. 遗传, 2003, 25(6):725-728.
[2] Urist M R. Bone:Formation by autoinduction[J].Science,1965, 150:893-899.
[3] Wozney J M, Rosen V, Celeste A J, et al. Novel regulators of bone formation:Molecular clones and activities[J]. Science, 1988, 242(4885):1528-1534.
[4] 钱丽丽,贾青,冯安学,等. BMP15基因CDS序列的生物信息学分析[J].黑龙江畜牧兽医(科技版),2010,11(上):46-48.
[5] 杨燕燕,达来,曹贵方,等. 影响绵羊多胎性状主效基因的研究进展[J]. 畜牧与饲料科学, 2009, 30(3):15-17.
[6] 储明星, 桑林华, 狄冉,等. 骨形态发生蛋白15基因的研究进展[J]. 中国畜牧兽医, 2008, 35(10):54-57.
[7] 甘霏霏, 钱卫平. 骨形态发生蛋白15在卵巢生殖调控过程中的作用[J]. 医学综述, 2010, 16(6):814-816.
[8] 王瑞,刘永斌,王峰,等. 骨形态发生蛋白BMP15基因的研究进展[J]. 畜牧与饲料科学, 2008, 3:67-69.
[9] 王旭, 买买提伊明·巴拉提. 国内绵羊高繁殖力基因的研究和应用[J].中国草食动物,2010,30(4):58-63.
[10] Hanrahan J P, Gregan S M, Mulsant P, et al. Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)[J]. Bio Reprod, 2004, 70(4):900-909.
[11] Peng J, Wigglesworth K, Rangarajan A,et al. Amino acid 72 of mouse and human GDF9 mature domain is responsible for homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities[J]. Biology of Reproduction, 2014, 91(6):142.
[12] Paulini F, Melo E O. The role of oocyte-secreted factors GDF9 and BMP15 in follicular development and oogenesis[J]. Reprod Domest Anim, 2011, 46(2):354-361.
[13] Gilchrist R B, Lane M, Thompson J G. Oocyte-secreted factors:Regulators of cumulus cell function and ooyte quality[J]. Hum Reprod Update, 2008, 14(2):159-177.
[14] Wan Q H, Wang Y X, Wang H Y. Identification and analysis of regulatory elements in porcine bone morphogenetic protein 15 gene promoter[J]. Int J Mol Sci, 2015,16:25759-25772.
[15] Kona S S, Praveen C V, Siva K A V,et al. Quantitative expression patterns of GDF9 and BMP15 genes in sheep ovarian follicles grown in vivo or cultured in vitro[J]. Theriogenology, 2016, 85(2):315-322.
[16] 金雯雯,王德迪,潘增祥,等.湖羊和巴什拜羊BMP15基因c-1760C>A变异与启动子区活性的关系[J].南京农业大学学报,2016,39(4):632-639.
[17] Galloway S M, McNatty K P, Cambridge L M, et al.Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner[J]. Nature Genetics, 2000, 25:279-283.
[18] Juengel J L, Hudson N L, Heath D A,et al. Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep[J]. Biology of Reproduction, 2002, 67:1777-1789.
[19] Bodensteiner K J, Clay C M, Moeller C L,et al. Molecular cloning of the ovine growth/differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries[J]. Biology of Reproduction, 1999, 60(2):381-386.
[20] Mandon-Pepin B, Oustry-Vaiman A, Vigier B, et al. Expression profiles and chromosomal localization of genes controlling meiosis and follicular development in the sheep ovary[J]. Biology of Reproduction, 2003, 68(3):985-995.
[21] Aaltonen J, Laitinen M P, Vuojolainen K, et al. Human growth differentiation factor 9(GDF-9) and its novel homolog GDF-9B are expected in oocytes during early folliculogenesis[J]. Journal of Clinical Endocrinology and Metabolism, 1999, 84:2744-2750.
[22] Eckery D C, Whale L J, Lawrence S B, et al. Expression of mRNA encoding growth differentiation factor 9 and bone morphogenetic protein 15 during follicular formation and growth in a marsupial, the brushtail (Trichosurus vulpecula)[J]. Molecular and Cellular Endocrinology, 2002, 192(1-2):115-126.
[23] Erickson G F,Shimasaki S. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary types during the oestrous cycle[J]. Reproductive Biology and Endocrinology, 2003, 1:1-21.
[24] Pierre A,Estienne A, Racine C, et al. The bone morphogenetic protein 15 up-regulates the anti-Müllerian hormone receptor expression in granulosa cells[J]. J Clin Endocrinol Metab, 2016, 101(6):2602-2611.
[25] Otsuka F, Yamamoto S, Erickson G F, et al. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression[J]. J Biol Chem, 2001, 276(14):11387-11392.
[26] Patricia D, Gerard K. The family of bone morphogenetic proteins[J].Kideny Interational, 2000, 57:2207-2214.
[27] McNatty K P, Hudson N, Smith P, et al. The effects of superovulating sheep with mutations in ither the activin-like kinase (Alk6) or bone morphogenetic protein (BMP15) genes on ovulation rate and embryo production[J]. J Reprod Dev,2006,52:S39-S43.
[28] Caixeta E, Machado M, Ripamonte P,et al. Effects of FSH on the expression of receptors for oocyte-secreted factors and members of the EGF-like family during in vitro maturation in cattle[J]. Reproduction, Fertility and Development, 2012, 25(6):890-899.
[29] Chu M X, Sang L H, Wang J Y,et al.Study on BMP15 and GDF9 as candidate genes for prolificacy of Small tail Han sheep[J]. Acta Genetica Sinica, 2005, 32(1):38-45.
[30] Galloway S M, McNatty K P, Cambridge L M, et al. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner[J]. Nature Genetics, 2000, 25(3):279-283.
[31] Bodin L, Lecerf F, Pisselet C, et al. How many mutations are associated with increased ovulation rate and litter size in progeny of Lacaune meat sheep[A].Proceedings of the International Workshop on Major Genes and QTL in Sheep and Goat[C]. 2003.
[32] Guo W, Chu M X, Deng X M, et al. Association of a single codon deletion in bone morphogenetic protein 15 gene with prolificacy in Small tail Han sheep[J]. Asian-Aust J Anim Sci, 2004, 17(11):1491-1495.
[33] 储明星, 成荣, 陈国宏, 等. 小尾寒羊和湖羊高繁殖力候选基因BMP15的研究[J]. 安徽农业大学学报, 2005, 32(3):278-282.
[34] Su Y Q, Sugiura K,Wigglesworth K, et al. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes:BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells[J]. Development, 2008, 135:111-121.
[35] Polley S, De S, Brahma B,et al. Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep[J].Trop Anim Health Prod, 2010, 42(5):985-993.
[36] Roy J, Polley S, De S,et al. Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep[J].Anim Biotechnol, 2011, 22(3):151-162.
[37] Zhu C Y, Fan H Y,Yuan Z H, et al. Detection of selection signatures on the X chromosome three sheep breeds[J]. Int J Mol Sci, 2015, 16(9):20360-20374.
[38] Zamani P, Nadri S,Rezvan S, et al. A new mutation in exon 2 of the bone morphogenetic protein 15 gene is associated with increase in prolificacy of Mehraban and Lori sheep[J]. Tropical Animal Health and Production, 2015, 47(5):855-860.
[39] Nadri S, Zamani, Ahmadi A. Novel mutation in exon 1 of the BMP15 gene and its association with reproduction traits in sheep[J]. Animal Biotechnology, 2016, 27(4):256-261.
[40] 徐业芬, 李齐发, 李二林,等. 湖羊BMP2、BMP4、BMP6和BMP7基因mRNA表达水平与排卵数关系的研究[J]. 中国农业科学, 2009, 42(10):3655-3661.
[41] 吴丽丽,赵晓枫,张立凡,等. 湖羊BMPR-IB、BMP15和GDF9基因的RFLP分析[J]. 中国草食动物, 2011, 31(4):9-12.
[42] 黄顺国,额尔和花,王新燕,等. 绵羊多胎基因BMPR-IB,BMP15的研究进展[J]. 农业科学研究, 2007, 28(3):68-71.
[43] 杨燕燕, 邵凯, 达来, 等. BMP15基因作为影响蒙古羊双羔性状候选基因的研究[J]. 华北农学报, 2010, 25(1):44-49.
[44] 刘永斌,王峰,田春英, 等. 绵羊BMP15基因外显子单核苷酸多态性研究[J]. 中国草食动物,2008, 28(1):3-5.
[45] 陶萨茹拉, 王峰, 刘永斌, 等. 绵羊BMP15基因三个位点核苷酸多态性研究[J]. 内蒙古农业大学学报, 2009, 30(2):9-13.
[46] 刘永斌, 荣威恒, 王峰, 等. 蒙古羊BMP15和GDF9基因多态性与其产羔性能相关研究[J]. 畜牧与饲料科学, 2010,31(6-7):136-138.
[47] 孙红霞,田秀娥, 王永军.BMPR-IB、BMP15和GDF9基因作为滩羊繁殖性状主效候选基因的研究[J]. 西北农业学报, 2009, 18(5):17-21.
[48] 许斌, 顾亚玲, 李继伟. 宁夏滩羊、小尾寒羊及滩寒杂交群体BMP15基因和GDF9基因多态性研究[J]. 安徽农业科学, 2010, 38(19):10084-10087.
[49] 储明星, 孙洁, 陈宏权, 等. 绵羊BMP15基因Fec XL突变的检测[J]. 中国农学通报, 2007, 23(10):85-88.

Research Progress on the Relationship Between BMP15 Gene and Reproduction Performance of Sheep

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Saiqiao, ZHAO Lu, ZHAI Zhenhan, ZHANG Binglei, JIA Wanhang, WANG Yuqin. Tissue Expression and Bioinformatics Analysis of miR-449a/b Precursor Sequences in Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2175-2184.
[2]	ZHANG Fangwei, ZHANG Qi, LEI Liangliang, SUN Wusheng, ZHANG Di, ZHANG Yunpeng, ZHANG Jingbo, WANG Xiuquan, ZHANG Jing, ZHANG Shumin. Polymorphism of HBEGF Gene and Its Association with Reproductive Traits in Songliao Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2370-2379.
[3]	LIU Jinyu, ZHANG Yang, MA Xumei, ZHOU Qian, ZHOU Yang, ZHANG Chunxiang, SHI Lei, REN Youshe. Effects of Glutathione on Cryopreservation of Sheep Semen [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2388-2394.
[4]	ZHANG Huaqiang, WANG Pinsheng, LI Xiao, WEI Panpeng, YAN Lingmin, JIANG Bingbing, WANG Zhaogui, WANG Xuefang, ZENG Huanqing, FAN Yi, GAO Zhenglong, WANG Xuebing. Effects of Fermented Hybrid Broussonetia papyrifera on Growth Performance, Meat Quality,Digestive Enzyme Activity and Intestinal Flora Structure of Hu Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1876-1887.
[5]	ZHAO Qianming, QI Meng, XU Zeli, GONG Pihong, LU Chenyang, PEI Zhiyang, JIAN Fuchun, WANG Jiandong, JING Bo, NING Changsheng. Investigation of Intestinal Parasites Occurrence in Sheep and Environmental Contamination in Large-scale Housing Farms [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2156-2165.
[6]	ZHANG Fangwei, ZHANG Qi, ZHANG Yunpeng, LI Xin, ZHANG Jingbo, ZHANG Shumin, YU Yongsheng. Polymorphism of FOXA2 Gene Exon 3 and Its Association with Reproductive Traits in Songliao Black Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1444-1451.
[7]	CUI Shuang, Wurlig, Alder, XIAO Min, WANG Jianqiu, GONG Jian. Effects of Yeast Selenium Supplementation on Gastrointestinal Microflora in Sheep Under Grazing Conditions [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 952-965.
[8]	ZHANG Yongjie, SUI Zhiyuan, ZHANG Zhishuai, WANG Chenguang, LI Xiaojun, XING Feng. Cloning and Bioinformatics Analysis of NPTX1 Gene and Its Tissues Expression at Puberty in Dolang Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1048-1058.
[9]	ZHANG Mingliang, ZHANG Hailong, MA Shipeng, WANG Cailian, LANG Xia. Effects of Zanthoxylum bungeanum Essential Oil on Production Performance and Gastrointestinal Tissue Structure of Small-tail Han Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 556-563.
[10]	LI Chenglan, GUO Tingting, YUE Yaojing. Research Advances on Genomic Selection and Its Application in Sheep Breeding [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 616-625.
[11]	QIN Zhiyun, JIANG Huaizhi. An Overview of Research on Skin Hair Follicle Development and Regulatory Mechanism in Sheep During the Fetal Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 638-646.
[12]	AN Xiaopeng, LIU Nan, HU Zhengjiamei, HU Jincao, XU Xiaolong, ZHANG Lei, SONG Yuxuan. Comparative Analysis of Lactation Performance of East Friesen Sheep, Hu Sheep and East Friesen-Hu Hybrid Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 238-245.
[13]	LIU Gang, ZHU Fangxian, ZHANG Xiaowei, GU Feng, LIU Lijun, SU Rui, MENG Fei, XU Haitao, SUN Feizhou. Evaluation of Embryo and Sperm Cryopreservation in Hu Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3492-3499.
[14]	ZHANG Xueping, SHI Bingang, JIN Xiayang, WANG Xiangyan, LAN Lijuan, SHI Yu, QI Youpeng, ZHAO Shijie, LI Shaobin, HU Jiang. Expression Characterization Analysis of KLF7 Gene and Effects of Its Overexpression on Proliferation and Differentiation of Preadipocytes in Tibetan Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2920-2930.
[15]	LI Weidong, JIANG Yuting, DUAN Hongwei, HE Haijun, YANG Shuai, DING Ziqiang, WU Jianxin, ZHANG Enqiu, HU Junjie. Distribution and Expression of Melatonin Receptors MT1 and MT2 in Various Stomach Tissues of Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 3256-3262.