獭兔氟中毒模型的建立及各器官氟含量测定

doi:10.16431/j.cnki.1671-7236.2017.07.036

Abstract

Abstract:

In order to study the influence of different doses of sodium fluoride on rex rabbit,rex rabbit fluorosis model was established and the fluorine contents of blood,bone,liver,kidney and other organs in rex rabbit were examined to provide a theoretical reference for the further research. Rex rabbits (age (30±5) days,weight (1.1±0.2) kg) were divided into three groups:Control group,test group Ⅰ (10 mg/(kg·d) NaF group) and test group Ⅱ (20 mg/(kg·d) NaF group). The tests lasted 100 d. The results showed that,on the 100th day,fluoride contents of bone and tooth were significantly different (P<0.05),and they were positively correlated with the time and intake of fluoride;The fluoride contents of kidney and liver were slightly different (P>0.05),and they were not significantly different between both test groups (P>0.05).The fluoride contents of blood were not significantly different between group Ⅰ and group Ⅱ (P>0.05),but both had no significant changes compared with control group (P<0.05). Sodium fluoride as a fluoride source could be used to simulate the natural state of rex rabbit fluorine poisoning. The fluoride accumulating ability in bone and tooth were stronger while the ability in blood,liver and kidney were weaker.

Key words: rex rabbit; NaF; toxicology; fluorosis

CLC Number:

S858.291

WANG Liang, FAN Hong-jie. Establishment of the Rex Rabbit Fluorosis Model and Detection of the Fluoride Content in Organs[J]. , 2017, 44(7): 2160-2164.

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Establishment of the Rex Rabbit Fluorosis Model and Detection of the Fluoride Content in Organs

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