脂滴发育中代谢相关的结构蛋白研究进展

doi:10.16431/j.cnki.1671-7236.2017.05.010

Abstract

Abstract:

Generally, lipid droplets are storage of triglycerides in adipocytes, but recent researches indicate that the transport, storage and steatolysis mobilization of fat in the cells are all based on lipid droplets, various phenomena reveal that lipid droplets is not only a simple energy storage in cells, but also more of a multifunctional organelle. By analyzing the structure of lipid droplets, it has been found that with neutral fat as the core, lipid droplets are covered with single phospholipid and embedded with a variety of functional proteins, which are referred as lipid droplets associated proteins. Lipid droplets associated protein correlated with lipid droplets are involved in the regulation of lipid metabolism, membrane transport, signal transduction and other physiological processes in different forms. It can be divided into three categories according to the different bearing capacity of proteins, including lipid droplet structural protein, lipid droplet associated protein and lipid transport protein. Among them, structural proteins, such as proteins in the PAT family and CIDE family proteins, play important roles in the regulation of lipid droplet growth and metabolism.In addition, hormone-sensitive lipase, adipose triglyceride lipase and Rab protein, as well as other metabolism and transport proteins are suggested to be involved in lipid droplets development through different forms. At present, new types and mechanisms of lipid droplets related proteins are still being explored. This review is to address the research progress of lipid droplets, lipid metabolism and lipid droplets related proteins in cells.

Key words: adipocyte; metabolism; lipid droplet associated protein

CLC Number:

Q244

LUO Cheng-long, SHAO Wei, ZHAO Yan-kun, YU Xiong. Research Progress on Metabolic Related Structural Proteins in Lipid Droplet Development[J]. , 2017, 44(5): 1321-1328.

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Research Progress on Metabolic Related Structural Proteins in Lipid Droplet Development

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