山羊BMPR-IB基因编码蛋白结构及功能的生物信息学分析

doi:10.16431/j.cnki.1671-7236.2017.05.001

Abstract

Abstract:

This study was aimed to analyze the structure and function of BMPR-IB gene coding protein by bioinformatics. The primary structure, secondary structure, subcellular localization, tertiary structure, important functional motifs and functional classification of BMPR-IB gene coding protein in goat were predicted and analyzed by online softwares. Phylogenetic tree of BMPR-IB gene coding proteins of different species were constructed by maximum likelihood method and phylogenetic analysis was performed.The results showed that the goat BMPR-IB gene encoded 502 amino acids, its coding protein belonged to an unstable hydrophilic protein. Secondary structure was mainly beta-sheet (63.5%). The protein was mainly located in the nucleus, and also distributed in mitochondria, cytoplasm, vesicle secretion system and plasma membrane. The proteins mainly played the roles of purine and pyrimidine, regulation, transport and binding, signal transduction and so on. There were one transmembrane domains in the location of 127th to 149th amino acids, the GS domain in the location of 174th to 203th amino acids and the protein kinase domain in the location of 204th to 494th amino acids were highly conserved motifs. The tertiary structure consisted of sheet fragment structure enrichment domain and helix helical structure enrichment domain. The results of phylogenetic analysis of BMPR-IB gene in different species was consistent with the results of animal taxonomy, and suggested that BMPR-IB gene was associated with the fertility traits. The structure and function of BMPR-IB gene coding protein in goat were analyzed by different online prediction software, which provided theoretical guidance for further study ofBMPR-IB gene.

Key words: BMPR-IB gene; goat; bioinformatics; protein structure

CLC Number:

YANG Jia-dong, LIU Yue-qin, ZHANG Ying-jie. Bioinformatics Analysis of the Structure and Function of BMPR-IB Gene Coding Protein in Goat[J]. , 2017, 44(5): 1259-1266.

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Bioinformatics Analysis of the Structure and Function of BMPR-IB Gene Coding Protein in Goat

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