雄性生殖系统抗氧化研究进展

doi:10.16431/j.cnki.1671-7236.2016.05.031

Abstract

Abstract: It is believed that active metabolism in male reproductive tract is contributed to production of ROS (reactive oxygen species).Low physiological ROS plays a fundamental role in mammalian reproduction, but the excessive accumulation of potentially damaging ROS can affect the function of sperm.Thus, it is important to maintain normal reproductive ability by a protective mechanism against oxidative stress.Here, we review the progress of antioxidant enzymes and redox systems in male reproductive systems, in order to provide references for physiology and pathology researches in male animals.

Key words: spermatozoa; semen; oxidative stress; antioxidants; reproduction

CLC Number:

S814

FAN Xiao-mei, ZHANG Jia-xin. Research Progresses on Anti-oxidation in Male Reproductive Systems[J]. , 2016, 43(5): 1329-1334.

References

[1] Aitken R J,Smith T B,Jobling M S,et al.Oxidative stress and male reproductive health[J].Asian J Andrology,2014,16(1):31-38.
[2] Agarwal A,Ayaz A,Samanta L,et al.Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species[J].Clinical Proteomics,2015,12(1):1-20.
[3] Sellami A,Chakroun N,Rtaib Y,et al.Evaluation of the impact of leucocytospermia on semen oxidative status by chemiluminescence technique in infertile men[J].Advances in Bioscience and Biotechnology,2013,4(11):30-40.
[4] Gil-Guzman E,Ollero M,Lopez M C,et al.Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation[J].Human Reproduction,2001,16(9):1922-1930.
[5] Agarwal A,Saleh R A,Bedaiwy M A.Role of reactive oxygen species in the pathophysiology of human reproduction[J].Fertility and Sterility,2003,79(4):829-843.
[6] Barraud-Lange V,Pont J C,Ziyyat A,et al.Seminal leukocytes are good samaritans for spermatozoa[J].Fertility and Sterility,2011,96(6):1315-1319.
[7] Waheed M M,Gouda E M,Khalifa T A A.Impact of seminal plasma superoxide dismutase and glutathione peroxidase on cryopreserved buffalo spermatozoa[J].Animal Reproduction Science,2013,142(3-4):126-130.
[8] Garratt M,Bathgate R,de Graaf S P,et al.Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility[J].Reproduction,2013,146(4):297-304.
[9] Ishii T,Matsuki S,Iuchi Y,et al.Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress[J].Free Radical Research,2005,39(7):697-705.
[10] Wdowiak A,Bakalczuk S,Bakalczuk G.Decreased activity of superoxide dismutase in the seminal plasma of infertile men correlates with increased sperm deoxyribonucleic acid fragmentation during the first hours after sperm donation[J].Andrology,2015,3(4):748-755.
[11] Gu W,Hecht N B.Developmental expression of glutathione peroxidase,catalase,and manganese superoxide dismutase mRNAs during spermatogenesis in the mouse[J].Journal of Andrology,1996,17(3):256-262.
[12] Macanovic B,Vucetic M,Jankovic A,et al.Correlation between sperm parameters and protein expression of antioxidative defense enzymes in seminal plasma:A pilot study[J].Disease Markers,2015,Epub of publish.
[13] Raineri I,Carlson E,Gacayan R,et al.Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility[J].Free Radical Biology and Medicine,2001,31(8):1018-1030.
[14] Aitken R J,Roman S D.Antioxidant systems and oxidative stress in the testes[J].Advances in Experimental Medicine and Biology,2008,636(1):154-171.
[15] Kowalowka M,Wysocki P,Fraser L,et al.Extracellular superoxide dismutase of boar seminal plasma[J].Reproduction in Domestic Animals,2008,43(4):490-496.
[16] Peeker R,Abramsson L,Marklund S L.Superoxide dismutase isoenzymes in human seminal plasma and spermatozoa[J].Molecular Human Reproduction,1997,3(12):1061-1066.
[17] Lubos E,Loscalzo J,Handy D E.Glutathione peroxidase-1 in health and disease:From molecular mechanisms to therapeutic opportunities[J].Antioxidants and Redox Signaling,2011,15(7):1957-1997.
[18] Ahsan U,Kamran Z,Raza I,et al.Role of selenium in male reproduction-A review[J].Animal Reproduction Science,2014,146(1-2):55-62.
[19] Ho Y S,Magnenat J L,Bronson R T,et al.Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia[J].Journal of Biological Chemistry,1997,272(26):16644-16651.
[20] Burk R F,Olson G E,Winfrey V P,et al.Glutathione peroxidase-3 produced by the kidney binds to a population of basement membranes in the gastrointestinal tract and in other tissues[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2011,301(1):G32-G38.
[21] Noblanc A,Kocer A,Chabory E,et al.Glutathione peroxidases at work on epididymal spermatozoa:An example of the dual effect of reactive oxygen species on mammalian male fertilizing ability[J].Journal of Andrology,2011,32(6):641-650.
[22] Imai H,Suzuki K,Ishizaka K,et al.Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males[J].Biology of Reproduction,2001,64(2):674-683.
[23] Yant L J,Ran Q,Lin R,et al.The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults[J].Free Radical Biology and Medicine,2003,34(4):496-502.
[24] Conrad M,Moreno S,Sinowatz F,et al.The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability[J].Molecular and Cellular Biology,2005,25(17):7637-7644.
[25] Hirotaka I,Nao H,Ryo I,et al.Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice[J].Journal of Biological Chemistry,2009,284(47):32522-32532.
[26] Bao Y,Jemth P,Mannervik B,et al.Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases[J].Febs Letters,1997,410(2-3):210-212.
[27] Chabory E,Damon C,Lenoir A,et al.Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice[J].Journal of Clinical Investigation,2009,119(7):2074-2085.
[28] Vernet P,Rock E,Mazur A,et al.Selenium-independent epididymis-restricted glutathione peroxidase 5 protein(GPX5) can back up failing Se-dependent GPXs in mice subjected to selenium deficiency[J].Molecular Reproduction and Development,1999,54(4):362-370.
[29] Jeulin C,Soufir J C,Weber P,et al.Catalase activity in human spermatozoa and seminal plasma[J].Gamete Research,1989,24(2):185-196.
[30] Amini M R,Kohram H,Shahaneh A Z,et al.The effects of different levels of catalase and superoxide dismutase in modified Beltsville extender on rooster post-thawed sperm quality[J].Cryobiology,2015,70(3):226-232.
[31] Wdowiak A,Bakalczuk S,Bakalczuk G.Decreased activity of superoxide dismutase in the seminal plasma of infertile men correlates with increased sperm deoxyribonucleic acid fragmentation during the first hours after sperm donation[J].Andrology,2015,3:748-755.
[32] O'Flaherty C,de Souza A R.Hydrogen peroxide modifies human sperm peroxiredoxins in a dose-dependent manner[J].Biology of Reproduction,2011,84(2):238-247.
[33] O'Flaherty C.Peroxiredoxins:Hidden players in the antioxidant defence of human spermatozoa[J].Basic and Clinical Andrology,2014,24(4):1-10.
[34] Gong S,San G M C,Arm Z,et al.Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men[J].Journal of Andrology,2012,33(6):1342-1351.
[35] Smith T B,Baker M A,Connaughton H S,et al.Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress[J].Free Radical Biology and Medicine,2013,65(4):872-881.
[36] Newick K,Cunniff B,Preston K,et al.Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma Cells[J].PLoS One,2012,7(6):e39404.
[37] Surai P F,Fisinin V I.Selenium in pig nutrition and reproduction:Boars and semen quality-A review[J].Asian-Australasian Journal of Animal Sciences,2015,28(5):730-746.
[38] Strzezek J.Secretory activity of boar seminal vesicle gland[J].Reproductive Biology,2002,2:243-266.
[39] Grosshans K,Calvin H I.Estimation of glutathione in purified populations of mouse testis germ cells[J].Biol Reprod,1985,33(5):1197-1205.
[40] Maiorino M,Ursini F.Oxidative stress,spermatogenesis and fertility[J].Biological Chemistry,2002,383(3-4):591-597.
[41] Raijmakers M T,Roelofs H M,Steegers E A,et al.Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa[J].Fertil Steril,2003,79(1):169-172.
[42] Estrada E,Rodríguez-Gil J E,álamo M M R D,et al.Effects of reduced glutathione on acrosin activity in frozen-thawed boar spermatozoa[J].Reproduction Fertility and Development,2015,10:1071.
[43] Gadea J,Gumbao D,Gómez-Giménez B,et al.Supplementation of the thawing medium with reduced glutathione improves function of frozen-thawed goat spermatozoa[J].Reprod Biol,2013,13(1):24-33.
[44] Gadea J,Molla M,Selles E,et al.Reduced glutathione content in human sperm is decreased after cryopreservation:Effect of the addition of reduced glutathione to the freezing and thawing extenders[J].Cryobiology,2011,62(1):40-46.

Research Progresses on Anti-oxidation in Male Reproductive Systems

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	SUN Chen, GE Sheng, NING Xiaqing, WANG Jiaqi, ZHANG Nuannuan, WANG Xiaoran, ZHANG Shixia. Oxidative Stress Model of BRL-3A Cells Induced by Sodium Hydrosulfite [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2217-2223.
[2]	WANG Jing, SONG Hongbing, WU Yanling, LIN Weimin, XIAO Tianfang. Research Progress of Crocin in Animal Antioxidants [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2233-2244.
[3]	LI Rui, ZHANG Yiyang, LUO Xuehui, ZHOU Manlin, WU Shaomi, YANG Kun, QIAO Zilin. Effect of Hypoxia on Proliferation and Oxidative Stress Injury of Pulmonary Artery Smooth Muscle Cells in Yaks [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2245-2254.
[4]	LYU Chunrong, LIANG Jiachong, SHAO Qingyong, WU Guoquan, ZHANG Yumei, QUAN Guobo. Effects of Sodium Pyruvate on the Quality of Frozen Goat Sperm [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2363-2369.
[5]	LIU Jinyu, ZHANG Yang, MA Xumei, ZHOU Qian, ZHOU Yang, ZHANG Chunxiang, SHI Lei, REN Youshe. Effects of Glutathione on Cryopreservation of Sheep Semen [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2388-2394.
[6]	LI Yongqiang, BAO Ruiying, WANG Qin, QIU Pingfei, LI Xiaochun, SHI Huiyu, ZHANG Haiwen, WANG Xuemei. Protective Effects of Antioxidant Peptides from Maggot on Oxidative Stress Injury of IPEC-J2 Cells [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1836-1844.
[7]	SONG Chenglei, ZHANG Zhe, WEI Yilin, YANG Songbai, DOU Yaqing, LI Chenlei, LIU Yingke, LI Xinjian, YANG Feng, LI Xiuling, WANG Kejun, QIAO Ruimin, HAN Xuelei. Effects of Different Breeds,Seasons and Month Ages on Semen Quality of Boars [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1938-1946.
[8]	ZHANG Jinwu, WEI Zi, JI Yutong, WU Changxu, LI Zhenmin, WEI Yingyi, HU Tingjun, YU Meiling. Study on Oxidative Stress and Inflammatory Injury in Intestinal Tract of Yellow-feathered Chickens Induced by Clostridium perfringens Type A [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2069-2081.
[9]	DU Zhaohui, GE Zihao, YOU Junyi, LIU Xiaowei, LIANG Guodong, SUN Shiduo, HU Jianhong, LI Xiao. Effects of Clostridium butyricum and Sodium Butyricum on Reproductive System Injury Induced by High Fat Diet in Male Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1603-1616.
[10]	DOU Jiahong, WANG Ziying, YANG Juan, ZHOU Weiwei, ZHANG Tongcun, HE Hongpeng, DAI Xiaofeng, LI Xiumei. Analysis of the Active Ingredients and Mechanism of Radix Paeoniae Rubra Antioxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1229-1240.
[11]	CHEN Jin, XIE Jinghao, HAN Yingqian, YANG Yanbin, WANG Yueying, LI Heping. Anti-inflammatory and Antioxidant Effects of Euphorbiae humifusae Aqueous Extract in IPEC-J2 Cells [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 704-712.
[12]	LIU Bo, LI Meilin, LIU Xu, LIANG Shuangying, MU Baolong, ZHAO Wenting, GE Yansong. Effects of Adipose-derived Stem Cell Conditioned Medium Alleviates Oxidative Stress Injury Induced by Sodium Taurocholate and Trypsin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 798-806.
[13]	FU Jingcheng, HE Junhui, TONG Jiang, WU Wei, GUO Shuang, YANG Yanbin, HAN Yingqian, WANG Yueying, LI Heping. Anti-inflammatory and Antioxidant Roles of HO-1 in Macrophages [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 807-816.
[14]	ZHANG Xiaoke, LIAO Weili, LI Tingting, LI Yao, LI Jiaqi, HUANG Xiang, ZHANG Hao. Effects of Semen Collectors and Environmental Parameters in Pigpen on Semen Quality of Duroc Boars [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 220-229.
[15]	MIAO Weiyuan, ZHANG Siqi, HUANG Changqiao, ZHAO Yi, CHEN Qi, XIE Xiaodong, WEI Yingyi, YU Meiling, HU Tingjun. Effect of N-butanol Fraction of Polygonum hydropiper Flavonoids on Levels Oxidative Stress-related Factors in 3D4/2 Cells Infected with PRV [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 349-358.