Abstract: In order to research the dynamic changes of nutrient intake and serum biochemical indexes of barn feeding ewes in different pregnant stages, and provide evidence for reasonable diet formulation and health state analysis of barn feeding goats, each 10 healthy female goats in non-pregnancy, early pregnancy and late pregnancy were randomly selected in this experiment, whose feed intake were determined;6 ill parturient ewes and each 8 healthy female goats in non-pregnancy, 1 month pregnancy, 2 months pregnancy, 3 months pregnancy, 4 months pregnancy and labor were randomly selected in this experiment, whose 7 serum biochemical indexes were determined.The results showed as follows:① In comparison to NRC(2007) goat nutritional requirements, DM, ME and CP intakes were more than the requirements in non-pregnant and early pregnant ewes, while DM, ME and CP intakes were less than the requirements in late pregnant ewes;Ca and P intakes were much more than the requirements in various stages of ewes.② From non-pregnancy, pregnancy to labor, healthy ewes' GLU content decreased (3.44 to 2.57 mmol/L) and KB content increased (14.93 to 23.55 μg/mL), while ill parturient ewes'GLU content was significantly decreased to 0.85 mmol/L(P<0.05) and KB content was significantly increased to 42.98 μg/mL (P<0.05);Healthy ewes' TP content decreased (70.55 to 59.94 g/L) and ALB content had little change (33.55 to 32.61 g/L), while ill parturient ewes' TP and ALB content both further decreased (56.79 and 29.72 g/L, respectively);Healthy ewes' Ca and P content had little change (2.21 to 2.19, 2.62 to 2.25 mmol/L, respectively), while ill parturient ewes' Ca (1.80 mmol/L, P<0.05) and P (2.17 mmol/L) content both decreased;Healthy ewes'AKP content decreased (258.57 to 104.35 U/L), but ill parturient ewes'AKP content increased (180.53 U/L).All the analysis showed that the inadequate energy intake of ewes in late pregnancy was the root cause of the decreased GLU and other serum biochemical indexes contents and the increased KB contents and the ill parturient ewes was diagnosed as pregnancy toxemia.Therefore, the ewes'diet formulation should be adjusted, different stages of ewes should be separated to feed, the energy intake of ewes in late pregnancy should be increased.

Key words: barn feeding; female goats; pregnancy; nutrient intake; serum biochemical indexes; pregnancy toxemia