救必应中药血清与抗菌药联合对产ESBLs细菌抑菌效果的研究

doi:10.16431/j.cnki.1671-7236.2015.04.036

Abstract

Abstract: This research was aimed to investigate the Chinese material medica serum of Holly Bark combined with antimicrobials to induce in vitro antibacterial activity of bacteria. The Chinese material medica serum of Holly Bark was prepared. The minimal inhibition concentration (MIC) of antimicrobials were tested through twice micro-dilution method. Extended spectrum β-lactamases (ESBLs)-producing bacteria were induced and subcultured by the Chinese material medica serum of Holly Bark combined with antimicrobials. The Chinese material medica serum of Holly Bark combined with antimicrobials to induce bacteria passage for drug-resistant E. coli had antibacterial activity to a different extent. The effects of β-lactam antibiotics, aminoglycosides, quinolones and kaba oxygen against drug-resistant E. coli were obviously strengthened when combined with the Chinese material medica serum of Holly Bark in vitro.

Key words: Holly Bark; Chinese material medica serum; extended spectrum β-lactamases-producing bacteria; combined induction; minimal inhibition concentration (MIC)

CLC Number:

S859.7

SI Hong-bin, SONG Jian-wu, WANG Peng-xia, LI Hai-yan, LIU Zeng-yuan, SUN Yan-jie, ZHENG Yan-qing, HUANG Kai, XIA Juan. Study on the Antibacterial Effect of Chinese Material Medica Serum of Holly Bark Combined with Antimicrobials on ESBLs-producing Bacteria[J]. , 2015, 42(4): 1009-1014.

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Study on the Antibacterial Effect of Chinese Material Medica Serum of Holly Bark Combined with Antimicrobials on ESBLs-producing Bacteria

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