金不换水提取物与抗菌药联合对含NDM-1不动杆菌的体外作用研究

doi:10.16431/j.cnki.1671-7236.2016.04.036

Abstract

Abstract: The study was aimed to investigate the antibacterial activity of NDM-1-producing Acinetobacter in vitro induced by water extracts of Stephania delavayi Diels combined with antibacterial agents, and provide reference for the utilization of Stephania delavayi Diels.The minimum inhibitory concentration (MIC) of water extracts of Stephania delavayi Diels and antibacterial agents were tested through twice micro-dilution method.NDM-1-producing Acinetobacter were induced and subcultured by the 1/2 MIC of water extracts of Stephania delavayi Diels combined with antibacterial agents.The results showed that the MIC of water extracts of Stephania delavayi Diels was 0.250 g/mL.The MIC of NDM-1-producing Acinetobacter was decreased obviously after inducing by 0.125 g/mL of water extracts of Stephania delavayi Diels combined with 8 antibacterial agents, such as ceftriaxone sodium, amoxicillin, cefotaxime sodium, mequindox, sulfamonomethoxine, ceftazidime, ceftiofur sodium and meropenem.Antibacterial activities of antibacterial agents against NDM-1-producing Acinetobacter were enhanced obviously by combining with water extracts of Stephania delavayi Diels, and this combination could inhibit NDM-1-producing Acinetobacter to a certain degree.

Key words: Stephania delavayi Diels; NDM-1-producing Acinetobacter; combined induction

CLC Number:

R285

WU Yong-ji, LIU Zeng-yuan, PANG Zhen-yu, SUN Yan-jie, ZHAO Yu-chuan, HU Mei, LIN Li-liang, YAN Ze-hao, HUANG Kai, SI Hong-bin. Study on the Effects of Stephania delavayi Diels Water Extracts Combined with Antibiotics on NDM-1-producing Acinetobacter in Vitro[J]. , 2016, 43(4): 1092-1097.

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Study on the Effects of Stephania delavayi Diels Water Extracts Combined with Antibiotics on NDM-1-producing Acinetobacter in Vitro

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