MDA5在先天性免疫抗病毒作用中的研究进展

doi:10.16431/j.cnki.1671-7236.2015.01.036

Abstract

Abstract: Melanoma differentiation-associated gene-5 (MDA5) was a nucleic acid receptor in the cytoplasm, in combination with pathogen-associated molecular patterns (PAMPs), which specifically recognized a long double-stranded RNA, function was similar with retinoic acid-inducude gene Ⅰ (RIG-Ⅰ), after CARD-CARD interaction, it was combinated with the adaptor protein MAVS (also called VISA, Cardif or IPS-1), the interaction might result in the reposition of RLRs in intima, one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes, thereby activating the transcription factor NF-κB; on the other side it recruited TRAF3 and TBK1, thereby promoting phosphorylated activation of IRF3, after activations of the transcription factor NF-κB and IRF, they would enter the nucleus, and work together to promote the expression of type Ⅰ interferon gene.

Key words: MDA5; adaptor protein; phosphorylation; type Ⅰ interferon

CLC Number:

S852.4

LIU Huan-huan, XIE Li-jun, SHAO Zhi-yong, GAO Hong, YAN Yu-lin. Research Progress on Antiviral Effect of MDA5 in Innate Immunity[J]. , 2015, 42(1): 230-233.

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Research Progress on Antiviral Effect of MDA5 in Innate Immunity

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