[1] FINKEL T,HOLBROOK N J.Oxidants,oxidative stress and the biology of ageing[J].Nature,2000,408(6809):239-247. [2] TANG T K.Free radical theory of erythrocyte aging[J].Journal of the Formosan Medical Association,1997,96(10):779-783. [3] BRIEGER K,SCHIAVONE S,MILLER F J,et al.Reactive oxygen species:From health to disease[J]. Swiss Medical Weekly,2012,142:13659. [4] 刘朝巍,张涛,杨卓.氧化应激损伤线粒体参与癫痫病理过程[J].中国病理生理杂志,2008,1:198-200. LIU Z W,ZHANG T,YANG Z.Oxidative stress damage to mitochondria mediated the pathological processes in epilepsy[J].Chinese Journal of Pathophysiology,2008,1:198-200.(in Chinese) [5] 林迎晖,张家俊,陈文为.阿魏酸钠对大鼠肝线粒体氧化损伤的保护作用[J].药学学报,1994,29(3):171-175. LIN Y H,ZHANG J J,CHEN W W.Protective effect of sodium ferulate on damage of the rat liver mitochondria induced by oxygen free radicals[J]. Acta Pharmacologica Sinica,1994,29(3):171-175.(in Chinese) [6] SUN Y,OBERLEY L W.Redox regulation of transcriptional activators[J].Free Radical Biology & Medicine,1996,21:335-348. [7] 胡流芳,王迎,任汝静,等.Keap1-Nrf2/ARE信号通路的抗氧化应激作用及其调控机制[J].国际药学研究杂志,2016,43(1):146-152. HU L F,WANG Y,REN R J,et al.Anti-oxidative stress actions and regulation mechanisms of Keap1-Nrf2/ARE signal pathway[J].International Journal of Pharmaceutical Sciences Review and Research,2016,43(1):146-152.(in Chinese) [8] MOI P,CHAN K,ASUNIS I,et al.Isolation of NF-E2-related factor 2(Nrf2),a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandemNF-E2/AP1 repeat of the f-globin locus control region[J].Proceedings of the National Academy of Sciences of the United States of America,1994,91(21):9926-9930. [9] TRACHOOTHAM D,LU M,OGASAWARA M A,et al.Redox regulation of cell survival[J].Antioxidants & Redox Signal,2008,10(8):1343-1374. [10] LI W,YU S W,KONG A N.Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain[J].The Journal of Biological Chemistry,2006,281(37):27251-27263. [11] KATSUOKA F,MOTOHASHI H,ISHⅡ T,et al.Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes[J].Molecular and Cellular Biology,2005,25(18):8044-8051. [12] PLAFKER K S,NGUYEN L,BARNECHE M,et al.The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2[J].The Journal of Biological Chemistry,2010,285(30):23064-23074. [13] NIOI P,MCMAHON M,ITOH K,et al.Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:Quinone oxidoreductase 1 gene:Reassessment of the ARE consensus sequence[J].The Biochemical Journal,2003,374(2):337-348. [14] NIOI P,NGUYEN T,SHERRATT P J,et al.The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation[J].Molecular and Cell Biology,2005,25(24):10895-10906. [15] KATOH Y,ITOH K,YOSHIDA E.et al.Two domains of Nrf2 cooperatively bind CBP,a CREB binding protein,and synergistically activate transcription[J].Genes to Cells,2001,6(10):857-868. [16] KIM J H,YU S,CHEN J D,et al.The nuclear cofactor RAC3/AIB1/SRC-3 Enhances Nrf2 signaling by interacting with transactivation domains[J].Oncogene,2013,2(4):514-527. [17] MCMAHON M,THOMAS N,ITOH K,et al.Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains,the redox sensitive Neh2 degron and the redox-insensitive Neh6 degron[J].The Journal of Biological Chemistry,2004,279(30):31556-31567. [18] CHOWDHRY S,ZHANG Y,McMahon M,et al.Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain,one of which can be modulated by GSK-3 activity[J].Oncogene,2013,32(32):3765-3781. [19] CUADRADO A.Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP[J].Free Radical Biology and Medicine,2015,88,147-157. [20] WANG H,LIU K,GENG M,et al.RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2[J].Cancer Research,2013,73(10):3097-3108. [21] ITOH K,WAKABAYASHI N,KATOH Y,et al.Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain[J].Genes & Development,1999,13(1):76-86. [22] URUON A,MOTOHASHI H.The Keap1-Nrf2 system as an in vivo sensor for electrophiles[J].Nitric Oxide-biology and Chemistry,2011,25(2):153-160. [23] 蔡维霞,张军,胡大海.氧化和化学应激的防御性转导通路-Nrf2/ARE[J].中国生物化学与分子生物学报,2009,25(4):297-303. CAI W X,ZHANG J,HU D H.Defensive pathway of Nrf2 ARE involved in oxidative and chemical stress[J].Chinese Journal of Biochemistry and Molecular Biology,2009,25(4):297-303.(in Chinese) [24] BAIRD L,DINKOVA-KOSTOVA A T.The cytoprotective role of the Keap1-Nrf2 pathway[J].Archives of Toxicology,2011,85(4):241-272. [25] OGURA T,TONG K I,MIO K,et al.Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening,double glycine repeat,and C-terminal domains[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(7):2842-2847. [26] QUINTI L,DAYAIAN N S,TRGER U,et al. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients[J].Proceedings of the National Academy of Sciences of the United States of America,2017,114(23):4676-4685. [27] TKACHEV V O,MENSHCHIKOVA E B,ZENKOV N K.Mechanism of the Nrf2/Keap1/ARE signaling system[J].Biochemistry,2011,76(4):407-422. [28] TURPAEV K T.Role of transcription factor AP-1 in integration of cell signaling systems[J].Molekuliarnaia Biologiia,2006,40(6):851-866. [29] LYAKHOVICH V V,VAVILIN V A,ZENKOV N K,et al.Active defense under oxidative stress.The antioxidant responsive element[J].Biochemistry,2006,71(9):962-974. [30] LO S C,HANNINK M.PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria[J].Experimental Cell Research,2008,314(8):1789-1803. [31] 孙玥.基于Keap1-Nrf2/ARE信号通路探讨中药新风胶囊改善类风湿关节炎心肺功能的机制研究[D].安徽:安徽中医药大学,2014. SUN Y.Effects research of Xin Feng capsules on improving cardiopulmonary function of rheumatoid arthritis and the research on its mechanism based on Keap1-NRF2-ARE pathway[D].Anhui:Anhui University of Traditional Chinese Medicine,2014.(in Chinese) [32] LI Q K,SINGH A,BISWAL S,et al.KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma[J]. Journal of Human Genetics,2011,56(3):230-234. [33] ZHANG D D,HANNINK M.Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemo preventive agents and oxidative stress[J].Molecular and Cellular Biology,2003,23(22):8137-8151. [34] 李慧,杨林.Nrf2抗氧化的分子调控机制[J].生物信息学,2018,16(1):1-6. LI H,YANG L.Molecular regulatory mechanism of Nrf2 antioxidant[J].Chinese Journal of Bioinformatics,2018,16(1):1-6.(in Chinese) [35] 吴志红,马燕芬,赵磊,等.Nrf2-ARE信号通路在机体氧化应激损伤中的作用及与其他信号通路的关系[J].畜牧与饲料科学,2016,37(3):42-48. WU Z H,MA Y F,ZHAO L,et al.Role of Nrf2-ARE pathway in oxidative stress injury and its relationship with other signaling pathways[J].Animal Husbandry and Feed Science,2016,37(3):42-48.(in Chinese) [36] LEONARD S S,XIA C,JIANG B H,et al.Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses[J].Biochemical and Biophysical Research Communications,2003,309(4):1017-1026. [37] TAN C,WEI H,SUN H,et al.Effects of dietary supplementation of oregano essential oil to sows on oxidative stress status,lactation feed intake of sows,and piglet performance[J].BioMed Research international,2015,2015:525218. [38] MENG Q,GUO T,LI G,et al.Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1[J].Journal of Animal Science and Biotechnology,2018,9:34. [39] XIE C,WU X,LONG C,WANG Q,et al.Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sow[J].BMC Veterinary Research,2016,12(1):243. [40] 刘莹莹,任慧波,张星,等.母猪日粮中添加低聚壳聚糖对哺乳仔猪生长、抗氧化能力和免疫功能的影响[J].中国畜牧兽医,2019,46(1):166-173. LIU Y Y,REN H B,ZHANG X,et al.Effect of oligo-chitosan supplemented in sow diet on growth,antioxidant capacity and immunologic function of suckling piglets[J].China Animal Husbandry & Veterinary Medicine,2019,46(1):166-173.(in Chinese) [41] DU X,CHEN L,HUANG D,et al.Elevated apoptosis in the liver of dairy cows with ketosis[J].Cellular Physiology and Biochemistry,2017,43(2):568-578. [42] CHENG X,YANG S,XU C,et al.Proanthocyanidins protect against β-hydroxybutyrate-induced oxidative damage in bovine endometrial cells[J].Molecules,2019,24(3):400. [43] ZHANG J F,BAI K W,SU W P,et al.Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase Ⅱ detoxifying enzyme systems in broiler chickens[J].Poultry Science,2018,97(4):1209-1219. [44] ARSHAD M S,ANJUM F M,ASGHAR A,et al.Lipid stability and antioxidant profile of microsomal fraction of broiler meat enriched with α-lipoic acid and α-tocopherol acetate[J].Journal of Agricultural and Food Chemistry,2011,59(13):7346-7352. [45] XU L,ZHANG H J,YUE H Y,et al.Low-current & high-frequency electrical stunning increased oxidative stress,lipid peroxidation,and gene transcription of the mitogen-activated protein kinase/nuclear factor-erythroid 2-relatedfactor 2/antioxidant responsive element (MAPK/Nrf2/ARE) signaling pathway in breast muscle of broilers[J]. Food Chemistry,2018,242:491-496. [46] XU L,ZHANG H,YUE H,et al.Gas stunning with CO2 affected meat color,lipid peroxidation,oxidative stress,and gene expression of mitogen-activated protein kinases,glutathione S-transferases,and Cu/Zn-superoxide dismutase in the skeletal muscles of broilers[J]. Journal of Animal Science and Biotechnology,2018,9:37. [47] KIM J,CHA Y N,SURH Y J.A protective role of nuclear factor-erythroid 2-related factor-2(Nrf2) in inflammatory disorders[J].Mutation Research,2010,690(1-2):12-23. [48] SUBEDI L,LEE J H,YUMNAM S,et al.Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-κB inhibition and Nrf2/HO-1 activation[J].Cells,2019,8(2):194. [49] LEE Y,LEE S,GADDE U,et al.Dietary Allium hookeri reduces inflammatory response and increases expression of intestinal tight junction proteins in LPS-induced young broiler chicken[J].Research in Veterinary Science,2017,112:149-155. [50] OWUSU A,CHOIO S H,PETROSIUTE A,et al.Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease:A review[J].Frontiers of Medicine,2014,9(1):46-56. [51] LEE M T,LIN W.C,WANG S Y,et al.Evaluation of potential antioxidant and anti-inflammatory effects of Antrodia cinnamomea powder and the underlying molecular mechanisms via Nrf2-and NF-κB -dominated pathways in broiler chickens[J].Poultry Science,2018,97(7):2419-2434. [52] KANG S,LEE J S,LEE H C,et al Phytoncide extracted from pinecone decreases LPS induced inflammatory responses in bovine mammary epithelial cells[J].Journal of Microbiology and Biotechnology,2016,26(3):579-587. [53] PENG X X,ZHANG S H,WANG X L,et al.Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in raw 264.7 macrophages[J].Chinese Medicine,2015,10:15. [54] SHI H Y,YAN S M,GUO Y M,et al.Vitamin A pretreatment protects NO-induced bovine mammary epithelial cells from oxidative stress by modulating Nrf2 and NF-κB signaling pathways[J].Journal of Animal Science,2018,96(4):1305-1316. |