›› 2008, Vol. 1 ›› Issue (11): 48-50.

• 生理生化 • 上一篇    下一篇

肿瘤坏死因子-α在脂肪组织中的作用

林亚秋,李瑞文,贺庆华   

  1. 西南民族大学生命科学与技术学院,成都 610041
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-11-20 发布日期:2008-11-20

Tumour Necrosis Factorα Regulates Adipose Tissue Mass

LIN Yaqiu, LI Ruiwen, HE Qinghua   

  1. College of Life Science and Technology,Southwest University for Nationalities,Chengdu 610041,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-11-20 Published:2008-11-20

摘要: 作为一种由脂肪细胞产生和分泌的多功能细胞因子,肿瘤胚死因子-α(TNF-α)除了在免疫系统中发挥作用外,其在脂肪组织中也具有重要的调控作用,如促进脂肪分解、抑制脂肪合成、抑制脂肪细胞分化、诱导脂肪细胞凋亡等。综合起来看,TNF-α可抑制动物的脂肪沉积。

关键词: TNF-α; 脂肪组织; 凋亡; 脂类代谢

Abstract: Produced and secreted by the adipocyte, tumor necrosis factoralpha (TNF-a) acts as a multifunctional cytokine. In addition to its established role in the immune system, TNF-a also exerted complex regulatory actions on adipose tissue, such as accelerating lipolysis, hindering lipogenesis and adipose cell differentiation and inducing adipose cell apoptosis. Bringing together all of these diverse actions, TNF-α appears to play a general role in reducing adipose tissue mass.

Key words: TNF-α; adipose tissue; apoptosis; lipid metobolism

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