›› 2009, Vol. 36 ›› Issue (12): 93-96.

• 遗传繁育 • 上一篇    下一篇

Kisspeptins/GPR54系统及其在动物性发育中的作用

张营1,2, 郁建锋1, 顾志良1   

  1. (1.常熟理工学院生物系, 常熟 215500; 2.苏州大学基础医学与生物科学学院, 苏州 215123)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-12-20 发布日期:2009-12-20
  • 通讯作者: 顾志良

Kisspeptins/GPR54 System and Puberty Onset

ZHANG Ying1,2, YU Jian-feng1, GU Zhi-liang1   

  1. (1.Department of Life Science and Technology, Changshu Institute of Technology, Changshu 215500, China;2.College of Preclinical Medicine and Biological Science, Soochow University, Suzhou 215123, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-12-20 Published:2009-12-20
  • Contact: GU Zhi-liang

摘要: 促性腺释放激素(gonadotropin-releasing hormone,GnRH)脉冲式释放的激活是动物性发育的关键。研究结果发现,kisspeptins/GPR54系统对GnRH脉冲式释放的激活起到了重要作用,是性发育启动的调节器。在kisspeptins/GPR54胞内信号通路方面的研究也已经证实,kisspeptins能通过GPR54受体激活多种信号,以发挥其它功能。另外,光周期、机体能量储备等也是影响动物性发育的重要因素。

关键词: GnRH; 下丘脑—垂体—性腺轴; kisspeptins/GPR54系统; 信号通路

Abstract: The activation of GnRH pulsatile release is a key step of animal sexual development. Studies show that kisspeptins/GPR54 system, playing a pivotal role in activation of GnRH pulsatile release, is a regulator of sexual development onset. Studies regarding the intracellular signaling pathways on kisspeptins/GPR54 confirm that kisspeptins can activate a wide variety of signals via GPR54 to exert the other roles. Additionally, some factors such as photoperiod and energy reserve affect animal sexual development remarkably.

Key words: GnRH; HPG; kisspeptins/GPR54 system; signaling pathway

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