顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展

›› 2012, Vol. 39 ›› Issue (1): 71-74.

顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展

廖申权, 戚南山, 吴彩艳, 吕敏娜, 袁建丰, 余劲术, 孙铭飞

广东省农业科学院兽医研究所广东省兽医公共卫生公共实验室,广东广州 510640

收稿日期:2011-05-31 修回日期:1900-01-01 出版日期:2012-01-20 发布日期:2012-01-20
通讯作者: 孙铭飞

Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa

LIAO Shen-quan, QI Nan-shan, WU Cai-yan, LV Min-na, YUAN Jian-feng, YU Jin-shu, SUN Ming-fei

Guangdong Common Lab of Veterinary Public Health,Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China

Received:2011-05-31 Revised:1900-01-01 Online:2012-01-20 Published:2012-01-20

摘要/Abstract

摘要： 糖酵解途径广泛存在于各类生物中,是顶复门原虫的主要供能方式。3-磷酸甘油醛脱氢酶是糖酵解途径的重要酶,与顶复门原虫的生存密切相关,可以作为抗寄生虫药物研发的重要靶标。文章主要从顶复门原虫糖酵解途径、3-磷酸甘油醛脱氢酶的基因分析、作用机理及应用等方面进行综述。

关键词: 顶复门原虫; 3-磷酸甘油醛脱氢酶; 药物靶标

Abstract: Glycolysis exists in various organisms. It is the major energetic process in apicomplexan parasites. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis,which closely related to the survival of parasites. GAPDH is proposed to be a potential target for antiparasitic drugs. This review will focus on glycolysis and the genetic analysis,mechanism and application of glyceraldehydes-3-phosphate dehydrogenase in Apicomplexa.

Key words: Apicomplexa; glyceraldehyde-3-phosphate dehydrogenase (GAPDH); drug target

中图分类号:

Q554

廖申权;戚南山;吴彩艳;吕敏娜;袁建丰;余劲术;孙铭飞. 顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展[J]. , 2012, 39(1): 71-74.

LIAO Shen-quan;QI Nan-shan;WU Cai-yan;LV Min-na;YUAN Jian-feng;YU Jin-shu;SUN Ming-fei. Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa[J]. , 2012, 39(1): 71-74.

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