3β和17β羟基类固醇脱氢酶的研究进展

›› 2011, Vol. 38 ›› Issue (8): 66-70.

3β和17β羟基类固醇脱氢酶的研究进展

董新星¹, 方美英¹, 陈刚²

1. 中国农业大学动物科技学院,北京 100193;2. 中国农业科学院农业质量标准与检测技术研究所,北京 100081

收稿日期:2010-12-21 修回日期:1900-01-01 出版日期:2011-08-20 发布日期:2011-08-20
通讯作者: 陈刚

Advance on 3β-Hydroxysteroid Dehydrogenase and 7β-Hydroxysteroid Dehydrogenase

DONG Xin-xing¹, FANG Mei-ying¹, CHEN Gang²

1. College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;2. Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences,Beijing 100081,China

Received:2010-12-21 Revised:1900-01-01 Online:2011-08-20 Published:2011-08-20

摘要/Abstract

摘要： 3β羟基类固醇脱氢酶(3β-hydroxysteroid dehydrogenase,3βHSDs)和17β羟基类固醇脱氢酶(17β-hydroxysteroid dehydrogenase,17βHSDs)是所有固醇类激素生成及激素活性和非活性之间互相转化的关键酶,对于维持哺乳动物体内激素之间的平衡、调节激素生成和代谢发挥着重要的作用。作者综述了3βHSDs和17βHSDs基因的结构及功能、表达及组织分布、基因的转录调控,以及两种酶与养猪生产间的关系。

关键词: 3β羟基类固醇脱氢酶; 17β羟基类固醇脱氢酶; 基因结构; 转录调控

Abstract: The two enzymes 3β-hydroxysteroid dehydrogenase (3βHSDs) and 17β-hydroxysteroid dehydrogenase(17βHSDs) are essential for the conversion of all steroid hormones from non-active to their active forms,which play an important role in regulating the balance between hormones and maintaining the normal physiological functions in mammals. Here we presented 3βHSDs and 17βHSDs gene molecular structure and function,tissu-specific expression,as well as regulation of transcription. Moreover,the relation of these two enzymes in pig production was also reviewed.

Key words: 3β-hydroxysteroid dehydrogenase; 17β-hydroxysteroid dehydrogenase; gene structure; transcription regulation

中图分类号:

Q554⁺.9

董新星;方美英;陈刚. 3β和17β羟基类固醇脱氢酶的研究进展[J]. , 2011, 38(8): 66-70.

DONG Xin-xing;FANG Mei-ying;CHEN Gang. Advance on 3β-Hydroxysteroid Dehydrogenase and 7β-Hydroxysteroid Dehydrogenase[J]. China Animal Husbandry & Veterinary Medicine, 2011, 38(8): 66-70.

[1]	翟哲, 陈思, 吴艳茹, 王雪梅, 李崇瑞, 刘志勇, 陈巧玲, 王凤阳, 杜丽, 李昌, 金宁一. 绵羊CCL19基因启动子活性分析及其转录调控元件筛选[J]. 中国畜牧兽医, 2022, 49(4): 1213-1222.
[2]	陈哲, 杨鹏霞, 雷明明, 陈佳彬, 闫乐艳. 鹅p21基因克隆、启动子分析及转录调控研究[J]. 中国畜牧兽医, 2022, 49(2): 405-415.
[3]	孙珂, 祝昊丹, 周俊明, 王丹丹, 俞正玉, 吕立新, 何孔旺, 李彬, 倪艳秀. 猪链球菌4型GalR蛋白的生物信息学分析及原核表达[J]. 中国畜牧兽医, 2021, 48(2): 443-449.
[4]	韩昆鹏, 段炼, 李婷婷, 王金玉, 张涛, 李国辉, 张跟喜, 薛倩. 京海黄鸡卵巢转录组研究:基因结构分析与新基因发掘注释[J]. , 2016, 43(4): 854-861.
[5]	王东旭;万家余;李忠义;孟珂音;高宏伟. PrP蛋白与Shadoo蛋白研究进展[J]. , 2011, 38(6): 215-217.
[6]	童亮;柴俊;张以芳;肖晶. 蓝舌病病毒基因产物及其生物学功能[J]. , 2010, 37(7): 132-135.