mTOR信号通路及其抑制剂的研究进展

中国畜牧兽医 ›› 2013, Vol. 40 ›› Issue (2): 36-41.

mTOR信号通路及其抑制剂的研究进展

张慧锋^1,2, 李妍¹, 白雪³, 刘珊⁴

1. 吉林医药学院,吉林吉林 132013;
2. 吉林大学生命科学学院,吉林长春 130012;
3. 中国农业科学院,北京 100193;
4. 天津胸科医院,天津 300051

收稿日期:2012-06-13 出版日期:2013-02-20 发布日期:2013-02-06
通讯作者: 李妍,女,副教授,研究方向:免疫学。
作者简介:张慧锋(1980-),女,山东人,讲师,博士生,研究方向:药理学。
基金资助:
吉林省教育厅十二五科学技术规划项目(2011420);吉林省教育厅十二五科学技术规划项目(2011423)。

Reasearch Progress on mTOR Pathway and its Inhibitors

ZHANG Hui-feng^1,2, LI Yan¹, BAI Xue³, LIU Shan⁴

1. Jilin Medical College, Jilin 132013, China;
2. College of Life Sciences, Jilin University, Changchun 130012, China;
3. Chinese Academy of Agricultural Sciences, Beijing 100193, China;
4. Tianjin Chest Hospital, Tianjin 300051, China

Received:2012-06-13 Online:2013-02-20 Published:2013-02-06

摘要/Abstract

摘要： 哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR) 是进化上十分保守的丝氨酸/苏氨酸蛋白激酶,mTOR信号通路异常与肿瘤及神经退行性疾病密切相关,成为相关疾病治疗的靶点。除雷帕霉素及同系物外,姜黄素等抑制mTOR信号通路的中药单体物质不断被发现。作者对mTOR蛋白的结构、功能和mTOR信号通路及其抑制剂进行了综述。

关键词: mTOR蛋白; 信号通路; mTOR抑制剂

Abstract: Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase. The abnormal activities of mTOR signaling pathways are tightly related to tumorigenesis and neurodegenerative diseases. mTOR is a potential therapeutic target.Apart from rapamycin and homologues,many new mTOR inhibitors have come into market. The structure,function,signaling pathway and inhibitors of mTOR are reviewed in this article.

Key words: mTOR; signaling pathway; mTOR inhibitors

中图分类号:

Q756

张慧锋, 李妍, 白雪, 刘珊. mTOR信号通路及其抑制剂的研究进展[J]. 中国畜牧兽医, 2013, 40(2): 36-41.

ZHANG Hui-feng, LI Yan, BAI Xue, LIU Shan. Reasearch Progress on mTOR Pathway and its Inhibitors[J]. , 2013, 40(2): 36-41.

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