益生菌对肠道黏膜免疫影响的研究进展

›› 2013, Vol. 40 ›› Issue (2): 113-116.

益生菌对肠道黏膜免疫影响的研究进展

付连军¹, 郝景锋¹, 宋永利¹, 苗丽娟¹, 崔永镇²

1. 吉林农业科技学院动物医学学院,吉林吉林 132101;
2. 中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨 150001

收稿日期:2012-07-12 出版日期:2013-02-20 发布日期:2013-02-06
通讯作者: 郝景锋,男,黑龙江人,讲师,主要从事临床兽医学教学及研究工作。E-mail:hjfyhy@yahoo.com.cn E-mail:hjfyhy@yahoo.com.cn
作者简介:付连军(1969-),男,吉林人,硕士生,畜牧师,主要从事临床兽医学教学及研究工作。

Research Advance on Intestinal Mucosal Immunity of Probiotics

FU Lian-jun¹, HAO Jing-feng¹, SONG Yong-li¹, MIAO Li-juan¹, CUI Yong-zhen²

1. College of Veterinary Medicine, Jilin Agricultural Science and Technology College, Jilin 132101, China;
2. Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China

Received:2012-07-12 Online:2013-02-20 Published:2013-02-06

摘要/Abstract

摘要： 一些选择性益生菌株具有抑制肠道疾病炎性因子产生、稳定菌群、改善肠道黏膜免疫系统的功能。结合炎症性肠炎(inflammatory bowel disease,IBD),介绍某些选择性益生菌(probiotics)通过调节炎性细胞因子1β-白介素、γ-干扰素的表达,改善肠道黏膜炎症,控制疾病的进一步恶化。作者将从肠道黏膜的重要性,益生菌与Toll样受体、核转录因子(NF-κB)的关系,以及益生菌对肠道黏膜免疫影响等方面进行论述,进而探讨其作用机制,为进一步研究益生菌调节宿主肠道黏膜免疫提供新的思路。

关键词: 选择性益生菌株; 炎性因子; 肠道黏膜免疫

Abstract: Some selective probiotic strains could inhibit the production of intestinal disease inflammatory factors,stabilize microflora,improve function of intestinal mucosal immune system. This selected probiotics improved intestinal mucosal inflammation and regulated the expression of inflammatory cytokine IL-1β,INF-γ by combining the inflammatory bowel disease (IBD) to control further progress of the disease. The aim was to explore its mechanism for providing new ideas that probiotics regulated intestinal mucosal immunity. The importance of intestinal mucosa,relation probiotics with Toll-like receptors and NF-κB,impact of probiotics on intestinal mucosal immunity were reviewed in the paper.

Key words: selective probiotic strains; inflammatory factor; intestinal mucosal immunity

中图分类号:

S816.7

付连军, 郝景锋, 宋永利, 苗丽娟, 崔永镇. 益生菌对肠道黏膜免疫影响的研究进展[J]. , 2013, 40(2): 113-116.

FU Lian-jun, HAO Jing-feng, SONG Yong-li, MIAO Li-juan, CUI Yong-zhen. Research Advance on Intestinal Mucosal Immunity of Probiotics[J]. , 2013, 40(2): 113-116.

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