对乙酰氨基酚琥珀酸酯的合成及其表征分析

›› 2012, Vol. 39 ›› Issue (3): 220-223.

对乙酰氨基酚琥珀酸酯的合成及其表征分析

金超^1,2, 靳晓优¹, 唐文¹, 周涛¹, 符华林^1,2

1. 四川农业大学动物医学院,四川雅安 625014;2. 动物疫病与人类健康四川省重点实验室,四川雅安 625014

收稿日期:2011-09-14 修回日期:1900-01-01 出版日期:2012-03-20 发布日期:2012-03-20
通讯作者: 符华林

Study on the Synthesis of Paracetamol Succinate and its Characteristics

JIN Chao^1,2, JIN Xiao-you¹, TANG Wen¹, ZHOU Tao¹, FU Hua-lin^1,2

1. College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China;2. Key Labroatory of Animal Disease and Human Health of Sichuan Province,Ya'an 625014,China

Received:2011-09-14 Revised:1900-01-01 Online:2012-03-20 Published:2012-03-20

摘要/Abstract

摘要： 本研究以对乙酰氨基酚(APAP)和琥珀酸酐为原料,4-二甲氨基吡啶(DMAP)作催化剂,丙酮作溶剂,经一步反应合成对乙酰氨基酚琥珀酸酯(AP-S);以AP-S产率为指标,采用正交试验设计考察了原料配比、溶媒用量、反应温度、反应时间等因素的影响;分别采用化学鉴定法、熔点测定法、pH测定法、紫外扫描法(UV)、红外扫描法(IR)和高效液相法(HPLC)对AP-S进行鉴定。结果表明,产物表征符合AP-S特征,AP-S最佳合成条件为:琥珀酸酐与APAP摩尔比2∶1,催化剂0.15 g,丙酮30 mL,反应温度60 ℃,反应时间6 h。在优化条件下,AP-S收率可达81.7%。

关键词: 对乙酰氨基酚琥珀酸酯; 4-二甲氨基吡啶; 合成工艺; 表征

Abstract: Paracetamol succinate(AP-S) was synthesized from paracetamol and succinic anhydride by using 4-dimethylaminopyridine (DMAP) as catalyst and acetone as solvent. AP-S yield was selected as the main index, the synthetic technology was optimized by an orthogonal design including factors such as raw material monomer ratio, solvent dosage, reaction temperature, reaction time and so on. Characteristics of AP-S were identified by chemical identification, pH test, melting point test, IR, UV and HPLC. In result, the features of resultants was consistant with AP-S. The optimized synthetic technology was succinic anhydride and paracetamol monomer ratio 2∶1, catalyst 0.15 g, acetone 30 mL, temperature 60 ℃ and time 6 h, and the yield was 81.7%.

Key words: paracetamol succinate; DMAP; synthesis technology; characteristics

中图分类号:

R971.1

金超;靳晓优;唐文;周涛;符华林;. 对乙酰氨基酚琥珀酸酯的合成及其表征分析[J]. , 2012, 39(3): 220-223.

JIN Chao;JIN Xiao-you;TANG Wen;ZHOU Tao;FU Hua-lin;. Study on the Synthesis of Paracetamol Succinate and its Characteristics[J]. , 2012, 39(3): 220-223.

[1]	王凯茹, 毛雅楠, 徐瑞涛, 赵兴华, 何欣. 恩诺沙星新盐的制备、表征及溶解性研究[J]. 中国畜牧兽医, 2022, 49(10): 4032-4041.
[2]	杨玉帅, 李泽, 金天明, 杨升. 烯丙孕素-β-环糊精水溶性衍生物包合物的制备及表征[J]. 中国畜牧兽医, 2021, 48(11): 4094-4104.
[3]	梁子敬, 张景艳, 张凯, 王磊, 王旭荣, 张康, 李建喜. 基于Web of Science^TM的“多糖表征”研究论文产出分析[J]. 《中国畜牧兽医》, 2018, 45(3): 830-840.