DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用

›› 2012, Vol. 39 ›› Issue (12): 133-136.

DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用

蒙丽娜, 罗婷, 柯浩, 刘晓华, 孙洪亮, 陆凤花, 石德顺

广西大学亚热带农业生物资源保护与利用国家重点实验室,广西南宁 530004

收稿日期:2012-04-20 出版日期:2012-12-20 发布日期:2012-12-19
通讯作者: 石德顺,男,研究员,从事动物胚胎工程与转基因动物研究。E-mail: ardsshi@gxu.edu.cn;陆凤花,女,研究员,从事动物胚胎工程与转基因动物研究。E-mail: lfhgggg@163.com E-mail:ardsshi@gxu.edu.cn; lfhgggg@163.com
作者简介:蒙丽娜(1986-),女,广西人,硕士生,研究方向:胚胎生物工程。
基金资助:
国家"863"项目(2011AA100607);国家自然科学基金项目(31072033);教育部高等学校博士学科点博导基金项目(20114501110001);广西杰青项目(2012GXNSFFA060004);广西科学基金项目(2010GXNSFF013002);广西优秀人才资助计划(2010-1-1)。

Application of DNA Methyltransferase Inhibitors in Animal Somatic Cell Nuclear Transfer Research

MENG Li-na, LUO Ting, KE Hao, LIU Xiao-hua, SUN Hong-liang, LU Feng-hua, SHI De-shun

State Key Laboratory of Conservation & Utilization of Subtropical Agro-bioresources,Guangxi University,Nanning 530004,China

Received:2012-04-20 Online:2012-12-20 Published:2012-12-19

摘要/Abstract

摘要： 甲基化对胚胎发育和机体形成具有重要的调控作用,体细胞核移植胚胎常常表现出异常的DNA甲基化,DNA甲基转移酶抑制剂能抑制细胞的DNA甲基化水平,从而达到提高体细胞核移植效率的作用。作者主要综述了DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用。

关键词: DNA甲基化; DNA甲基转移酶抑制剂; 体细胞核移植

Abstract: Methylation plays an important regulatory role in embryo development and organization. Somatic nuclear transfer embryos often show the abnormal mode of DNA methylation, DNA methyltransferase inhibitors can inhibit the levels of DNA methylation, so as to improve the efficiency of SCNT.The application of DNA methyltransferase inhibitors in animal somatic cell nuclear transfer was taken an overview in this paper.

Key words: DNA methylation; DNA methyltransferase inhibitors; somatic cell nuclear transfer

中图分类号:

Q345⁺.21

蒙丽娜, 罗婷, 柯浩, 刘晓华, 孙洪亮, 陆凤花, 石德顺. DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用[J]. , 2012, 39(12): 133-136.

MENG Li-na, LUO Ting, KE Hao, LIU Xiao-hua, SUN Hong-liang, LU Feng-hua, SHI De-shun. Application of DNA Methyltransferase Inhibitors in Animal Somatic Cell Nuclear Transfer Research[J]. , 2012, 39(12): 133-136.

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