›› 2011, Vol. 38 ›› Issue (5): 62-65.

• 生理生化 • 上一篇    下一篇

一氧化氮在动物低氧适应中的生理和分子机制

王秀娟, 杨舒黎, 李帅, 刘情, 苟潇   

  1. 云南农业大学动物营养与饲料科学重点实验室,云南昆明 650201
  • 收稿日期:2010-09-13 修回日期:1900-01-01 出版日期:2011-05-20 发布日期:2011-05-20
  • 通讯作者: 苟潇

Physiological and Molecular Mechanism of Nitric Oxide in Animal Hypoxia Adaptation

WANG Xiu-juan, YANG Shu-li, LI Shuai, LIU Qing, GOU Xiao   

  1. Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming 650201,China
  • Received:2010-09-13 Revised:1900-01-01 Online:2011-05-20 Published:2011-05-20

摘要: 近年来,国内外学者在对高原民族和高原动物低氧适应相关基因的探索中揭示了藏族的低氧适应生理机制;高含量的一氧化氮(nitric oxide,NO)舒张血管并导致高速度的血流,高速度的血流弥补了高海拔低氧。可见一氧化氮在动物低氧适应中起着重要的作用。作者对低氧条件下一氧化氮的合成、传递、生物学效应及调控表达机制进行了综述。

关键词: 一氧化氮; 一氧化氮合酶; 低氧适应

Abstract: In recent years, hypoxia adaptation-related genetic study of plateau residents and animals has been researched by experts domestic and overseas, and they have revealed its physiological mechanism of Tibetans, which is, a high-flux Nitric oxide (NO) will relax blood vessel and then increase blood flow velocity which offsets the high altitude hypoxia. Obviously, nitric oxide has played an important role in hypoxia adaptation. The authors reviewed its synthesis, transmission, biological effect and its regulation and expression mechanism under the circumstance of hypoxia.

Key words: nitric oxide; nitric oxide synthase; hypoxia adaptation

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