氨苄西林混悬液在鸡体内的药物动力学及其生物利用度研究

›› 2010, Vol. 37 ›› Issue (6): 176-179.

氨苄西林混悬液在鸡体内的药物动力学及其生物利用度研究

刘志亮1，余祖功2，李丽杰1，裴香玲1，乔彦良1，闫祥华1，马凤龙1

（1.山东信得科技股份有限公司，青岛 266061； 2.南京农业大学，南京 210095）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-20 发布日期:2010-06-20

Study of Pharmacokinetics and Bioavailability of Ampicillin Suspension in Fowl

LIU Zhi-liang1，YU Zu-gong2，LI Li-jie1，PEI Xiang-ling1，QIAO Yan-liang1，YAN Xiang-hua1，MA Feng-long1

(1.Shandong Sinder Technology Corporation，Qingdao 266061, China; 2.Nanjing Agricultural University，Nanjing 210095, China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-06-20 Published:2010-06-20

摘要/Abstract

摘要： 作者对10%氨苄西林混悬液在靶动物-鸡体内的药物动力学及生物利用度进行了研究，结果表明,10%氨苄西林混悬液吸收迅速，达峰时间快，约0.89 h即达峰值；消除半衰期较短，约2.5 h；绝对生物利用度为35.27%，略高于氨苄西林溶液剂的绝对生物利用度（34.30%）；氨苄西林混悬液在鸡口服给药后的生物等效性为109.8%。

关键词: 氨苄西林混悬液; 药物动力学; 消除半衰期; 绝对生物利用度

Abstract: This article studied the pharmacokinetics and bioavailability of 10% Ampicillin suspension in vivo of target animal-fowl. The result showed that the absorption of 10% Ampicillin suspension was quick; the reaching peak time was short，about 0.89 h; the elimination half-life was about 2.5 h; and the absolute bioavailability was 35.27%，lightly higher than the absolute bioavailability of Ampicillin solution (34.30%); the bioequivalence of 10% Ampicillin suspension with oral administration to fowl was 109.8%. 

Key words: Ampicillin suspension; wlimination half-life; absolute bioavailability; bioequivalence

中图分类号:

S859.79⁺6

刘志亮;余祖功;李丽杰;裴香玲;乔彦良;闫祥华;马凤龙. 氨苄西林混悬液在鸡体内的药物动力学及其生物利用度研究[J]. , 2010, 37(6): 176-179.

LIU Zhi-liang;YU Zu-gong;LI Li-jie;PEI Xiang-ling;QIAO Yan-liang;YAN Xiang-hua;MA Feng-long. Study of Pharmacokinetics and Bioavailability of Ampicillin Suspension in Fowl [J]. China Animal Husbandry & Veterinary Medicine, 2010, 37(6): 176-179.

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