磺胺二甲嘧啶生理药动学模型种间类推的应用

›› 2010, Vol. 37 ›› Issue (3): 194-197.

磺胺二甲嘧啶生理药动学模型种间类推的应用

罗显阳，远立国

（华南农业大学兽医学院，广州 510642）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-20 发布日期:2010-03-20

The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model

LUO Xian-yang,YUAN Li-guo

(College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642，China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-03-20 Published:2010-03-20

摘要/Abstract

摘要： 本研究应用磺胺二甲嘧啶在猪的生理药动学模型来预测其在绵羊体内的动力学过程。利用文献中已经建立的猪的生理模型，采用动物种间类推原理，将模型外推至绵羊，模拟磺胺二甲嘧啶在绵羊体内的血药和组织浓度，并估算可食性组织残留休药期。结果模拟休药期和文献休药期基本趋于一致，表明生理药动学模型种间类推是可行的。

关键词: 磺胺二甲嘧啶; 生理药动学模型; 绵羊

Abstract: The objective of this paper was to predict kinetic process of Sulfamethazine in sheep on the basis of the physiologically based pharmacokinetic model of Sulfamethazine in pig.The PBPK model in pig was extrapolated to sheep based on the interspecies scaling theory, to simulate the plasma and tissues concentration of Sulfamethazine and estimate residue withdrawal times in edible tissues in sheep. The results showed that the simulated withdrawal times was according to the reported withdrawal times. The interspecies extrapolation of PBPK model was feasible.

Key words: Sulfamethazine; physiologically based pharmacokinetic model; sheep

中图分类号:

S859.7

罗显阳;远立国. 磺胺二甲嘧啶生理药动学模型种间类推的应用[J]. , 2010, 37(3): 194-197.

LUO Xian-yang;YUAN Li-guo. The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model[J]. , 2010, 37(3): 194-197.

[1]	马玲, 陈凤莲, 凌丹, 李志源, 骆永泉, 李丹, 张怡轩, 吴健敏. 广西主要动物源性产品中磺胺二甲嘧啶残留调查与分析[J]. 《中国畜牧兽医》, 2018, 45(11): 3286-3295.
[2]	龚云飞;王唯芬;张明洲;陈宗伦;奚茜;李沐洁. 禽类食品中磺胺二甲嘧啶间接竞争ELISA检测方法的建立[J]. , 2011, 38(6): 55-59.
[3]	欧仁福; 魏星华; 郑晓华; 沈明浩. 磺胺二甲嘧啶免疫抗原的合成研究[J]. , 2010, 37(6): 160-163.
[4]	魏星华;郑晓华;张田田;沈明浩. 磺胺二甲嘧啶对小鼠亚慢性毒性、骨髓细胞微核及精子畸形的影响[J]. , 2010, 37(5): 119-122.
[5]	崔嘉;孙守荣;苗鲁旭;席冬梅;何奕多;毛华明;邓卫东. TYRP1基因控制动物色素形成的研究进展[J]. , 2009, 36(9): 94-96.
[6]	杨亮;刘太宇;王艳玲;石科 . 麦秸-苜蓿型全混合日粮阴阳离子平衡对绵羊血液生化指标及氮平衡的影响[J]. , 2008, 1(10): 29-32.
[7]	穆晓峰. 饲料舔块饲喂绵羊效果试验[J]. , 2007, 34(3): 29-30.