地锦草抗宫颈癌活性研究

›› 2010, Vol. 37 ›› Issue (3): 192-193.

地锦草抗宫颈癌活性研究

玮罕¹，耿果霞¹，李青旺^1，2，李健²，田永芝^3

（1.西北农林科技大学动物科技学院，杨凌 712100； 2.燕山大学环化学院生物工程系，秦皇岛 066004；3.新疆石河子大学动物科技学院，石河子 832003）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-03-20 发布日期:2010-03-20
通讯作者: 李青旺

Study on Anti-cervical Cancer Activity of Euphorbia Humifusa

WEI Han¹, GENG Guo-xia¹, LI Qing-wang^1,2, LI Jian², TIAN Yong-zhi³

(1.College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; 2.Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, Qinhuangdao 066004, China;3.Department of Animal Science and Technology, Shihezi University, Shihezi 832003, China)

Received:1900-01-01 Revised:1900-01-01 Online:2010-03-20 Published:2010-03-20
Contact: LI Qing-wang

摘要/Abstract

摘要： 地锦草临床上多用于治疗菌痢、肠炎、病毒性肝炎、咳血、尿血、便血等。本试验通过建立小鼠U14宫颈癌模型，利用水煎法得到水提物，根据抑瘤率和对突变型p53蛋白表达的影响来研究地锦草水提物体内抗宫颈癌活性。结果表明，地锦草水提物能够显著抑制肿瘤生长，同时能使肿瘤组织的突变型p53蛋白的表达量显著下调。这可能是地锦草水提物抗肿瘤作用的潜在机制。

关键词: 地锦草; U14宫颈癌; p53蛋白

Abstract:

Euphorbia humifusa is always used to cure bacillary dysentery，enteritis，virus hepatitis，coughing up blood，blood urine，blood feces. This study using cervical cancer-bearing mice models investigated the anti-cervical activity of Euphorbia humifusa which was extracted by decoction according to tumor inhibition rate and the effect on expression of mutant p53 protein. It was obvious that the aqueous extract of Euphorbia humifusa could inhibit growth of tumor and significantly down regulate the expression of mutant p53 protein. This could be the potential mechanism of Euphorbia humifusa’s anti-tumor activity.

Key words: Euphorbia humifusa; U14 cervical cancer; p53

中图分类号:

S853.75

玮罕;耿果霞;李青旺;李健;田永芝. 地锦草抗宫颈癌活性研究[J]. , 2010, 37(3): 192-193.

WEI Han;GENG Guo-xia;LI Qing-wang;LI Jian;TIAN Yong-zhi. Study on Anti-cervical Cancer Activity of Euphorbia Humifusa[J]. , 2010, 37(3): 192-193.

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